Thyroid Hormone Reference Interval- Evidence from Alappuzha District, Kerala State, India
Introduction: Thyroid diseases are one of the most common endocrine disorders not only in India, but worldwide. Most commonly done biochemical tests to diagnose thyroid disorders are Thyrotropin (TSH), thyroid hormones {free thyroxine (FT4) and free triiodothyronine (FT3)} in serum. The Referen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-01-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2454/45616_CE[Ra1]_F(SHU)_PF1(ShG_SHU)_PFA(SHU_ShG)_PN(SHU).pdf |
| Summary: | Introduction: Thyroid diseases are one of the most common
endocrine disorders not only in India, but worldwide. Most
commonly done biochemical tests to diagnose thyroid
disorders are Thyrotropin (TSH), thyroid hormones {free
thyroxine (FT4) and free triiodothyronine (FT3)} in serum. The
Reference Interval (RI) is influenced by a variety of factors
like diet, genetics, iodine nutritional status and thyroid
autoimmunity. Hence, the reference values of thyroid function
tests commonly used in the clinical laboratories are derived
from data from the western population and may not be
applicable for Indian population.
Aim: To establish RI for thyroid hormones in the coastal area of
Alappuzha District in Kerala.
Materials and Methods: This community-based study
included 228 adults in the age group 18-80 years. TSH,
FT3, FT4, Thyroperoxidase antibody (TPOAb) and antithyroglobulin antibodies (TgAb) were analysed on an automated
immunoassay system Access 2 Beckman Coulter using a direct
chemiluminescence detection system. RIs were calculated
according to International Federation of Clinical Chemistry (IFCC)
recommendation using IBM SPSS version 20.0 for windows.
Results: RIs for serum TSH, FT4 and FT3 were calculated as
0.11-6.39 mIU/L, 0.58-4.66 ng/dL and 0.72-4.66 pg/mL. No
significant age and gender difference in the RIs are noted.
Conclusion: In this study, RI established in the local reference
population found to be different from those reported by previous
studies conducted in other geographical areas. |
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| ISSN: | 2277-8551 2455-6882 |