Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer
Abstract Background This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. Methods Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-021-02299-y |
| _version_ | 1818435197469720576 |
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| author | Tao Xue Kejing Yan Yiqi Cai Jiancheng Sun Zhejing Chen Xiaolei Chen Wenyi Wu |
| author_facet | Tao Xue Kejing Yan Yiqi Cai Jiancheng Sun Zhejing Chen Xiaolei Chen Wenyi Wu |
| author_sort | Tao Xue |
| collection | DOAJ |
| description | Abstract Background This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. Methods Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan–Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders. Results The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HROS = 0.183, 95% CI 0.052–0.647, P = 0.008; HRDFS = 0.191, 95% CI 0.078–0.470, P = 0.000). Conclusions The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS. |
| first_indexed | 2024-12-14T16:49:03Z |
| format | Article |
| id | doaj.art-380f66ec54de43b7bbc66db33b3d4a3e |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-14T16:49:03Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-380f66ec54de43b7bbc66db33b3d4a3e2022-12-21T22:54:07ZengBMCWorld Journal of Surgical Oncology1477-78192021-06-011911710.1186/s12957-021-02299-yPrognostic significance of CD163+ tumor-associated macrophages in colorectal cancerTao Xue0Kejing Yan1Yiqi Cai2Jiancheng Sun3Zhejing Chen4Xiaolei Chen5Wenyi Wu6Department of Traumatology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients. Methods Tissue microarray and immunohistochemistry were used to detect the infiltration of CD163+ TAMs in 209 CRC samples, and the Kaplan–Meier method was used for survival analysis. Cox proportional hazards analysis was used for univariate analysis and multivariate analysis of clinically relevant confounders. Results The samples were divided into low-level (n = 105) and high-level infiltration groups (n = 104) by the median number of CD163+ TAMs detected. The overall survival (OS) and disease-free survival (DFS) of CRC patients in the low-level CD163+ TAM infiltration group were longer than those in the high-level CD163+ TAM infiltration group (P < 0.001). Infiltration of CD163+ TAMs in CRC tissues was a negative prognostic factor for CRC patients. Risks of death and disease recurrence for CRC patients in the low-level CD163+ TAM infiltration group were lower than those in the high-level CD163+ TAM infiltration group (HROS = 0.183, 95% CI 0.052–0.647, P = 0.008; HRDFS = 0.191, 95% CI 0.078–0.470, P = 0.000). Conclusions The infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients. High-level infiltration of CD163+ TAMs is associated with shorter OS and DFS.https://doi.org/10.1186/s12957-021-02299-yColorectal cancerImmunohistochemistryCD163Tumor-associated macrophagesPrognosis |
| spellingShingle | Tao Xue Kejing Yan Yiqi Cai Jiancheng Sun Zhejing Chen Xiaolei Chen Wenyi Wu Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer World Journal of Surgical Oncology Colorectal cancer Immunohistochemistry CD163 Tumor-associated macrophages Prognosis |
| title | Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer |
| title_full | Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer |
| title_fullStr | Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer |
| title_full_unstemmed | Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer |
| title_short | Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer |
| title_sort | prognostic significance of cd163 tumor associated macrophages in colorectal cancer |
| topic | Colorectal cancer Immunohistochemistry CD163 Tumor-associated macrophages Prognosis |
| url | https://doi.org/10.1186/s12957-021-02299-y |
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