The Regulatory Properties of the Ccr4–Not Complex
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2379 |
| _version_ | 1827703182552203264 |
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| author | Nafiseh Chalabi Hagkarim Roger J. Grand |
| author_facet | Nafiseh Chalabi Hagkarim Roger J. Grand |
| author_sort | Nafiseh Chalabi Hagkarim |
| collection | DOAJ |
| description | The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair. In the cytoplasm, the Ccr4–Not complex plays a central role in mRNA decay and affects protein quality control. Most of our original knowledge of the Ccr4–Not complex is derived, primarily, from studies in yeast. More recent studies have shown that the mammalian complex has a comparable structure and similar properties. In this review, we summarize the evidence for the multiple roles of both the yeast and mammalian Ccr4–Not complexes, highlighting their similarities. |
| first_indexed | 2024-03-10T15:13:43Z |
| format | Article |
| id | doaj.art-38107e7006294fcbad96afebe4528dea |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:13:43Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-38107e7006294fcbad96afebe4528dea2023-11-20T19:06:42ZengMDPI AGCells2073-44092020-10-01911237910.3390/cells9112379The Regulatory Properties of the Ccr4–Not ComplexNafiseh Chalabi Hagkarim0Roger J. Grand1Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UKInstitute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UKThe mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair. In the cytoplasm, the Ccr4–Not complex plays a central role in mRNA decay and affects protein quality control. Most of our original knowledge of the Ccr4–Not complex is derived, primarily, from studies in yeast. More recent studies have shown that the mammalian complex has a comparable structure and similar properties. In this review, we summarize the evidence for the multiple roles of both the yeast and mammalian Ccr4–Not complexes, highlighting their similarities.https://www.mdpi.com/2073-4409/9/11/2379Ccr4–Not complexmRNA decaydeadenylationtranscriptioncell cyclechromatin modification |
| spellingShingle | Nafiseh Chalabi Hagkarim Roger J. Grand The Regulatory Properties of the Ccr4–Not Complex Cells Ccr4–Not complex mRNA decay deadenylation transcription cell cycle chromatin modification |
| title | The Regulatory Properties of the Ccr4–Not Complex |
| title_full | The Regulatory Properties of the Ccr4–Not Complex |
| title_fullStr | The Regulatory Properties of the Ccr4–Not Complex |
| title_full_unstemmed | The Regulatory Properties of the Ccr4–Not Complex |
| title_short | The Regulatory Properties of the Ccr4–Not Complex |
| title_sort | regulatory properties of the ccr4 not complex |
| topic | Ccr4–Not complex mRNA decay deadenylation transcription cell cycle chromatin modification |
| url | https://www.mdpi.com/2073-4409/9/11/2379 |
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