Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery
Anastomotic leakage is a potentially severe complication occurring after colorectal surgery and can lead to increased morbidity and mortality, permanent stoma formation, and cancer recurrence. Multiple risk factors for anastomotic leak have been identified, and these can allow for better prevention...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2382 |
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| author | Eugenia Claudia Zarnescu Narcis Octavian Zarnescu Radu Costea |
| author_facet | Eugenia Claudia Zarnescu Narcis Octavian Zarnescu Radu Costea |
| author_sort | Eugenia Claudia Zarnescu |
| collection | DOAJ |
| description | Anastomotic leakage is a potentially severe complication occurring after colorectal surgery and can lead to increased morbidity and mortality, permanent stoma formation, and cancer recurrence. Multiple risk factors for anastomotic leak have been identified, and these can allow for better prevention and an earlier diagnosis of this significant complication. There are nonmodifiable factors such as male gender, comorbidities and distance of tumor from anal verge, and modifiable risk factors, including smoking and alcohol consumption, obesity, preoperative radiotherapy and preoperative use of steroids or non-steroidal anti-inflammatory drugs. Perioperative blood transfusion was shown to be an important risk factor for anastomotic failure. Recent studies on the laparoscopic approach in colorectal surgery found no statistical difference in anastomotic leakage rate compared with open surgery. A diverting stoma at the time of primary surgery does not appear to reduce the leak rate but may reduce its clinical consequences and the need for additional surgery if anastomotic leakage does occur. It is still debatable if preoperative bowel preparation should be used, especially for left colon and rectal resections, but studies have shown similar incidence of postoperative leak rate. |
| first_indexed | 2024-03-10T04:17:51Z |
| format | Article |
| id | doaj.art-3810aaf7da744c8bb2187ae0e48acff2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:17:51Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-3810aaf7da744c8bb2187ae0e48acff22023-11-23T07:55:16ZengMDPI AGDiagnostics2075-44182021-12-011112238210.3390/diagnostics11122382Updates of Risk Factors for Anastomotic Leakage after Colorectal SurgeryEugenia Claudia Zarnescu0Narcis Octavian Zarnescu1Radu Costea2Department of General Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of General Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of General Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaAnastomotic leakage is a potentially severe complication occurring after colorectal surgery and can lead to increased morbidity and mortality, permanent stoma formation, and cancer recurrence. Multiple risk factors for anastomotic leak have been identified, and these can allow for better prevention and an earlier diagnosis of this significant complication. There are nonmodifiable factors such as male gender, comorbidities and distance of tumor from anal verge, and modifiable risk factors, including smoking and alcohol consumption, obesity, preoperative radiotherapy and preoperative use of steroids or non-steroidal anti-inflammatory drugs. Perioperative blood transfusion was shown to be an important risk factor for anastomotic failure. Recent studies on the laparoscopic approach in colorectal surgery found no statistical difference in anastomotic leakage rate compared with open surgery. A diverting stoma at the time of primary surgery does not appear to reduce the leak rate but may reduce its clinical consequences and the need for additional surgery if anastomotic leakage does occur. It is still debatable if preoperative bowel preparation should be used, especially for left colon and rectal resections, but studies have shown similar incidence of postoperative leak rate.https://www.mdpi.com/2075-4418/11/12/2382anastomotic leakageanastomotic fistularisk factorscolorectal surgerycolorectal cancer |
| spellingShingle | Eugenia Claudia Zarnescu Narcis Octavian Zarnescu Radu Costea Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery Diagnostics anastomotic leakage anastomotic fistula risk factors colorectal surgery colorectal cancer |
| title | Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery |
| title_full | Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery |
| title_fullStr | Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery |
| title_full_unstemmed | Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery |
| title_short | Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery |
| title_sort | updates of risk factors for anastomotic leakage after colorectal surgery |
| topic | anastomotic leakage anastomotic fistula risk factors colorectal surgery colorectal cancer |
| url | https://www.mdpi.com/2075-4418/11/12/2382 |
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