Saturated fatty acids differently affect mitochondrial function and the intestinal epithelial barrier depending on their chain length in the in vitro model of IPEC-J2 enterocytes

Saturated fatty acids differently affect mitochondrial function and the intestinal epithelial barrier depending on their chain length in the in vitro model of IPEC-J2 enterocytes

Introduction: Maintenance of the intestinal barrier mainly relies on the mitochondrial function of intestinal epithelial cells that provide ATP through oxidative phosphorylation (OXPHOS). Dietary fatty acid overload might induce mitochondrial dysfunction of enterocytes and may increase intestinal pe...

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Bibliographic Details
Main Authors: Thomas Guerbette, Vincent Rioux, Mégane Bostoën, Vincent Ciesielski, Hugo Coppens-Exandier, Marine Buraud, Annaïg Lan, Gaëlle Boudry
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intestine
mitochondria
barrier function
metabolism
fatty acids
enterocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1266842/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1266842/full

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