Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial
In post-stroke hemiparesis patients, the skeletal muscle mass decrease rapidly with the histological degradation. We investigated the effect of nutritional supplementation with whey protein and vitamin D on the muscle mass and muscle quality, in post-stroke convalescent rehabilitation patients in a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/685 |
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| author | Kaoru Honaga Naoki Mori Tomonori Akimoto Masahiro Tsujikawa Michiyuki Kawakami Tomoyuki Okamoto Yasuyuki Sakata Hirokazu Hamano Yasuhiro Takeda Kunitsugu Kondo |
| author_facet | Kaoru Honaga Naoki Mori Tomonori Akimoto Masahiro Tsujikawa Michiyuki Kawakami Tomoyuki Okamoto Yasuyuki Sakata Hirokazu Hamano Yasuhiro Takeda Kunitsugu Kondo |
| author_sort | Kaoru Honaga |
| collection | DOAJ |
| description | In post-stroke hemiparesis patients, the skeletal muscle mass decrease rapidly with the histological degradation. We investigated the effect of nutritional supplementation with whey protein and vitamin D on the muscle mass and muscle quality, in post-stroke convalescent rehabilitation patients in a randomized, single-blinded, placebo-controlled trial. Fifty patients were randomly assigned to two groups; HP group received supplemental jelly (100 kcal; whey protein 10 g; vitamin D 20 μg) twice a day throughout up to 16-week period, the control group received placebo jelly. Cross-sectional area (CSA) of thigh muscle, skeletal muscle index (SMI), muscle strength, activity of daily living (ADL), and some nutritional indicators in blood were measured. Although no significant difference was observed in CSA and SMI between the groups, fat infiltration into the thighs muscle was singnificantly lower in the HP group. There were no significant difference in muscle strength and ADL between the groups. Blood urea nitrogen and serum 25(OH)D at endpoint were significantly higher in the HP group but physiological normal ranges. Supplementation with whey protein and vitamin D in post-stroke patients led to suppression of fat infiltration into the muscle. Long-term follow-up studies are needed to verify whether this nutritional intervention provides substantial benefits for the prognosis of stroke survivors. |
| first_indexed | 2024-03-09T23:20:18Z |
| format | Article |
| id | doaj.art-38130269f6254911b6610a04d2702682 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:20:18Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-38130269f6254911b6610a04d27026822023-11-23T17:27:53ZengMDPI AGNutrients2072-66432022-02-0114368510.3390/nu14030685Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled TrialKaoru Honaga0Naoki Mori1Tomonori Akimoto2Masahiro Tsujikawa3Michiyuki Kawakami4Tomoyuki Okamoto5Yasuyuki Sakata6Hirokazu Hamano7Yasuhiro Takeda8Kunitsugu Kondo9Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, JapanDepartment of Rehabilitation Medicine, Hatsudai Rehabilitation Hospital, 3-53-3 Honmachi, Shibuya-ku, Tokyo 151-0071, JapanDepartment of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, JapanDepartment of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, JapanDepartment of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, JapanR & D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City 252-8583, JapanR & D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City 252-8583, JapanR & D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City 252-8583, JapanR & D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City 252-8583, JapanDepartment of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, JapanIn post-stroke hemiparesis patients, the skeletal muscle mass decrease rapidly with the histological degradation. We investigated the effect of nutritional supplementation with whey protein and vitamin D on the muscle mass and muscle quality, in post-stroke convalescent rehabilitation patients in a randomized, single-blinded, placebo-controlled trial. Fifty patients were randomly assigned to two groups; HP group received supplemental jelly (100 kcal; whey protein 10 g; vitamin D 20 μg) twice a day throughout up to 16-week period, the control group received placebo jelly. Cross-sectional area (CSA) of thigh muscle, skeletal muscle index (SMI), muscle strength, activity of daily living (ADL), and some nutritional indicators in blood were measured. Although no significant difference was observed in CSA and SMI between the groups, fat infiltration into the thighs muscle was singnificantly lower in the HP group. There were no significant difference in muscle strength and ADL between the groups. Blood urea nitrogen and serum 25(OH)D at endpoint were significantly higher in the HP group but physiological normal ranges. Supplementation with whey protein and vitamin D in post-stroke patients led to suppression of fat infiltration into the muscle. Long-term follow-up studies are needed to verify whether this nutritional intervention provides substantial benefits for the prognosis of stroke survivors.https://www.mdpi.com/2072-6643/14/3/685strokesarcopeniarehabilitationwhey proteinvitamin D |
| spellingShingle | Kaoru Honaga Naoki Mori Tomonori Akimoto Masahiro Tsujikawa Michiyuki Kawakami Tomoyuki Okamoto Yasuyuki Sakata Hirokazu Hamano Yasuhiro Takeda Kunitsugu Kondo Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial Nutrients stroke sarcopenia rehabilitation whey protein vitamin D |
| title | Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| title_full | Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| title_fullStr | Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| title_full_unstemmed | Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| title_short | Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| title_sort | investigation of the effect of nutritional supplementation with whey protein and vitamin d on muscle mass and muscle quality in subacute post stroke rehabilitation patients a randomized single blinded placebo controlled trial |
| topic | stroke sarcopenia rehabilitation whey protein vitamin D |
| url | https://www.mdpi.com/2072-6643/14/3/685 |
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