NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.
Surfactant protein D (SP-D) has important immuno-modulatory properties. The absence of SP-D results in an inducible NO synthase (iNOS, coded by NOS2 gene) related chronic inflammation, development of emphysema-like pathophysiology and alterations of surfactant homeostasis.In order to test the hypoth...
Main Authors: | Lars Knudsen, Elena N Atochina-Vasserman, Chang-Jiang Guo, Pamela A Scott, Beat Haenni, Michael F Beers, Matthias Ochs, Andrew J Gow |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3897517?pdf=render |
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