Assessment of a High Sensitivity Method for Identification of <i>IDH1</i> R132x Mutations in Tumors and Plasma of Intrahepatic Cholangiocarcinoma Patients

Assessment of a High Sensitivity Method for Identification of <i>IDH1</i> R132x Mutations in Tumors and Plasma of Intrahepatic Cholangiocarcinoma Patients

Hotspot codon 132 mutations (R132x<i>IDH1</i>m) are frequent in intrahepatic cholangiocarcinoma (ICC), are druggable by anti-<i>IDH1</i>m agents, and could represent a marker of disease progression. Developing an assay to identify R132x<i>IDH1</i>m would provide a...

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Bibliographic Details
Main Authors: Caterina Peraldo-Neia, Maria Scatolini, Enrico Grosso, Pasquale Lombardi, Roberto Filippi, Chiara Raggi, Caterina Marchiò, Giuliana Cavalloni, Massimo Aglietta, Francesco Leone
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
IDH1 mutation
intrahepatic cholangiocarcinoma
qPCR
liquid biopsy
biomarker
Online Access:https://www.mdpi.com/2072-6694/11/4/454

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