Sex differences in drug effects and/or toxicity in oncology
The prevalence, incidence, and severity of a wide variety of diseases and ailments are significantly influenced by the significant disparities that occur between the sexes. The way that men and women react to pharmacological treatment also varies. Therefore, it is crucial to comprehend these reactio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257122000724 |
| _version_ | 1827917700214554624 |
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| author | H.T. Rakshith S. Lohita Anvil Preem Rebello Prakash S. Goudanavar N. Raghavendra Naveen |
| author_facet | H.T. Rakshith S. Lohita Anvil Preem Rebello Prakash S. Goudanavar N. Raghavendra Naveen |
| author_sort | H.T. Rakshith |
| collection | DOAJ |
| description | The prevalence, incidence, and severity of a wide variety of diseases and ailments are significantly influenced by the significant disparities that occur between the sexes. The way that men and women react to pharmacological treatment also varies. Therefore, it is crucial to comprehend these reactions in order to conduct risk assessment correctly and to develop safe and efficient therapies. Even from that limited vantage point, the manner and timing of our drug usage might have unintended and unanticipated consequences. There are sex-specific differences in the incidence and mortality of certain malignancies. One of the most important discoveries in cancer epidemiology is the gender inequalities. Cancer incidence differences between the sexes are thought to be regulated at the genetic and molecular levels and by sex hormones like oestrogen. Differences based on sex and gender are among the least investigated factors impacting cancer susceptibility, progression, survival, and therapy response despite their established importance in clinical care. The molecular mechanisms underlying sex differences in particular are poorly known, hence the majority of precision medicine approaches employ mutational or other genetic data to assign therapy without taking into account how the patient's sex may affect therapeutic efficacy. In patients receiving chemotherapy, there are definite gender-dependent disparities in response rates and the likelihood of side effects. This review explores the influence of sex as a biological variable in drug effects or toxicity in oncology. |
| first_indexed | 2024-03-13T03:31:10Z |
| format | Article |
| id | doaj.art-38172fc1f6db4529a9767e28307b020c |
| institution | Directory Open Access Journal |
| issn | 2590-2571 |
| language | English |
| last_indexed | 2024-03-13T03:31:10Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj.art-38172fc1f6db4529a9767e28307b020c2023-06-24T05:19:01ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712023-01-014100152Sex differences in drug effects and/or toxicity in oncologyH.T. Rakshith0S. Lohita1Anvil Preem Rebello2Prakash S. Goudanavar3N. Raghavendra Naveen4Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448, IndiaDepartment of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448, IndiaDepartment of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448, IndiaDepartment of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448, IndiaDepartment of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448, India; Corresponding author.The prevalence, incidence, and severity of a wide variety of diseases and ailments are significantly influenced by the significant disparities that occur between the sexes. The way that men and women react to pharmacological treatment also varies. Therefore, it is crucial to comprehend these reactions in order to conduct risk assessment correctly and to develop safe and efficient therapies. Even from that limited vantage point, the manner and timing of our drug usage might have unintended and unanticipated consequences. There are sex-specific differences in the incidence and mortality of certain malignancies. One of the most important discoveries in cancer epidemiology is the gender inequalities. Cancer incidence differences between the sexes are thought to be regulated at the genetic and molecular levels and by sex hormones like oestrogen. Differences based on sex and gender are among the least investigated factors impacting cancer susceptibility, progression, survival, and therapy response despite their established importance in clinical care. The molecular mechanisms underlying sex differences in particular are poorly known, hence the majority of precision medicine approaches employ mutational or other genetic data to assign therapy without taking into account how the patient's sex may affect therapeutic efficacy. In patients receiving chemotherapy, there are definite gender-dependent disparities in response rates and the likelihood of side effects. This review explores the influence of sex as a biological variable in drug effects or toxicity in oncology.http://www.sciencedirect.com/science/article/pii/S2590257122000724OncologySex differencesChemotherapyPersonalized medicine |
| spellingShingle | H.T. Rakshith S. Lohita Anvil Preem Rebello Prakash S. Goudanavar N. Raghavendra Naveen Sex differences in drug effects and/or toxicity in oncology Current Research in Pharmacology and Drug Discovery Oncology Sex differences Chemotherapy Personalized medicine |
| title | Sex differences in drug effects and/or toxicity in oncology |
| title_full | Sex differences in drug effects and/or toxicity in oncology |
| title_fullStr | Sex differences in drug effects and/or toxicity in oncology |
| title_full_unstemmed | Sex differences in drug effects and/or toxicity in oncology |
| title_short | Sex differences in drug effects and/or toxicity in oncology |
| title_sort | sex differences in drug effects and or toxicity in oncology |
| topic | Oncology Sex differences Chemotherapy Personalized medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590257122000724 |
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