Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China
Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2011-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/17/2/10-0718_article |
| _version_ | 1818307207406551040 |
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| author | Cunwei Cao Ling Liang Wenjuan Wang Hong Luo Shaobiao Huang Donghua Liu Jianping Xu Daniel A. Henk Matthew C. Fisher |
| author_facet | Cunwei Cao Ling Liang Wenjuan Wang Hong Luo Shaobiao Huang Donghua Liu Jianping Xu Daniel A. Henk Matthew C. Fisher |
| author_sort | Cunwei Cao |
| collection | DOAJ |
| description | Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004–July 2005 across Guangxi Province, China, and demonstrated 100% prevalence of infection. Multilocus genotypes show that P. marneffei isolates from humans are similar to those infecting rats and are in some cases identical. Comparison of our dataset with genotypes recovered from sites across Southeast Asia shows that the overriding component of genetic structure in P. marneffei is spatial, with humans containing a greater diversity of genotypes than rodents. Humans and bamboo rats are sampling an as-yet undiscovered common reservoir of infection, or bamboo rats are a vector for human infections by acting as amplifiers of infectious dispersal stages. |
| first_indexed | 2024-12-13T06:54:43Z |
| format | Article |
| id | doaj.art-381863c67d0e4011b64db2ae8ffecf22 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-13T06:54:43Z |
| publishDate | 2011-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-381863c67d0e4011b64db2ae8ffecf222022-12-21T23:56:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592011-02-0117220921410.3201/eid1702.100718Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, ChinaCunwei CaoLing LiangWenjuan WangHong LuoShaobiao HuangDonghua LiuJianping XuDaniel A. HenkMatthew C. FisherHuman penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004–July 2005 across Guangxi Province, China, and demonstrated 100% prevalence of infection. Multilocus genotypes show that P. marneffei isolates from humans are similar to those infecting rats and are in some cases identical. Comparison of our dataset with genotypes recovered from sites across Southeast Asia shows that the overriding component of genetic structure in P. marneffei is spatial, with humans containing a greater diversity of genotypes than rodents. Humans and bamboo rats are sampling an as-yet undiscovered common reservoir of infection, or bamboo rats are a vector for human infections by acting as amplifiers of infectious dispersal stages.https://wwwnc.cdc.gov/eid/article/17/2/10-0718_articleFungal infectionsfungiPenicillium marneffeimicrosatellite typinggenotypezoonosis |
| spellingShingle | Cunwei Cao Ling Liang Wenjuan Wang Hong Luo Shaobiao Huang Donghua Liu Jianping Xu Daniel A. Henk Matthew C. Fisher Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China Emerging Infectious Diseases Fungal infections fungi Penicillium marneffei microsatellite typing genotype zoonosis |
| title | Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China |
| title_full | Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China |
| title_fullStr | Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China |
| title_full_unstemmed | Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China |
| title_short | Common Reservoirs for Penicillium marneffei Infection in Humans and Rodents, China |
| title_sort | common reservoirs for penicillium marneffei infection in humans and rodents china |
| topic | Fungal infections fungi Penicillium marneffei microsatellite typing genotype zoonosis |
| url | https://wwwnc.cdc.gov/eid/article/17/2/10-0718_article |
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