SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS
Identification of risk factors associated with presence of atrial fibrillation (AF) in patients with aortic valve stenosis (AS) remains to be unraveled.The aim of the study was to investigate relationship between profibrotic biomarkers and presence of AF in AS patientsMethods. 191 patients (29,8% ma...
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| Format: | Article |
| Language: | English |
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Eco-vector
2017-06-01
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| Series: | Клиническая практика |
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| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/8070/6492 |
| _version_ | 1797720109878345728 |
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| author | T A Tipteva O S Chumakova N E Reznichenko V I Safaryan T N Baklanova N M Voloshina D A Zateyshchikov |
| author_facet | T A Tipteva O S Chumakova N E Reznichenko V I Safaryan T N Baklanova N M Voloshina D A Zateyshchikov |
| author_sort | T A Tipteva |
| collection | DOAJ |
| description | Identification of risk factors associated with presence of atrial fibrillation (AF) in patients with aortic valve stenosis (AS) remains to be unraveled.The aim of the study was to investigate relationship between profibrotic biomarkers and presence of AF in AS patientsMethods. 191 patients (29,8% male, 77,7±0,59 years) with AS (defined as aortic valve area (AVA) ≤ 2,0 sm2) were enrolled in the study. Clinical, echocardiographic and biochemical variables, including serum TGFβ1 and osteopontin levels were compared between 2 groups of patients: with and without AF. Results. 83(36,5%) of AS patients had AF. In logistic regression models independent associations between AVA index (p=0,040), left atrial volume (p=0,021), OPN (р=0,009) and presence of AF were found. Patients with serum OPN level 10,05 ng/ml had twice more higher AF incidence comparedto patients with serum OPN level ≤ 10,05 ng/ml (53,8% and 29,2%, respectively, p=0,020).Conclusion. Serum OPN level was independently associated with presence of AF in AS patients, thus we speculate on it’s predominant profibrotic role in the left atrium. |
| first_indexed | 2024-03-12T09:15:45Z |
| format | Article |
| id | doaj.art-381894724c904f1d82ea09a3ee7a92e2 |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T09:15:45Z |
| publishDate | 2017-06-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-381894724c904f1d82ea09a3ee7a92e22023-09-02T14:50:25ZengEco-vectorКлиническая практика2220-30952618-86272017-06-018231310.17816/clinpract823-137516SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIST A TiptevaO S ChumakovaN E ReznichenkoV I SafaryanT N BaklanovaN M VoloshinaD A ZateyshchikovIdentification of risk factors associated with presence of atrial fibrillation (AF) in patients with aortic valve stenosis (AS) remains to be unraveled.The aim of the study was to investigate relationship between profibrotic biomarkers and presence of AF in AS patientsMethods. 191 patients (29,8% male, 77,7±0,59 years) with AS (defined as aortic valve area (AVA) ≤ 2,0 sm2) were enrolled in the study. Clinical, echocardiographic and biochemical variables, including serum TGFβ1 and osteopontin levels were compared between 2 groups of patients: with and without AF. Results. 83(36,5%) of AS patients had AF. In logistic regression models independent associations between AVA index (p=0,040), left atrial volume (p=0,021), OPN (р=0,009) and presence of AF were found. Patients with serum OPN level 10,05 ng/ml had twice more higher AF incidence comparedto patients with serum OPN level ≤ 10,05 ng/ml (53,8% and 29,2%, respectively, p=0,020).Conclusion. Serum OPN level was independently associated with presence of AF in AS patients, thus we speculate on it’s predominant profibrotic role in the left atrium.https://journals.eco-vector.com/clinpractice/article/viewFile/8070/6492tgfβ1aortic stenosisatrial fibrillation, osteopontintgfβ1fibrosis |
| spellingShingle | T A Tipteva O S Chumakova N E Reznichenko V I Safaryan T N Baklanova N M Voloshina D A Zateyshchikov SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS Клиническая практика tgfβ1 aortic stenosis atrial fibrillation, osteopontin tgfβ1 fibrosis |
| title | SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS |
| title_full | SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS |
| title_fullStr | SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS |
| title_full_unstemmed | SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS |
| title_short | SERUM OSTEOPONTIN LEVEL IS ASSOCIATED WITH PRESENCE OF ATRIAL FIBRILLATION IN CALCIFIC AORTIC VALVE STENOSIS |
| title_sort | serum osteopontin level is associated with presence of atrial fibrillation in calcific aortic valve stenosis |
| topic | tgfβ1 aortic stenosis atrial fibrillation, osteopontin tgfβ1 fibrosis |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/8070/6492 |
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