Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis
Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis.Methods: Studies associ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00002/full |
| _version_ | 1828525209544556544 |
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| author | Jiaxuan Qin Jiaxuan Qin Jiaxuan Qin Yufeng Yang Yufeng Yang Yufeng Yang Xuan Zhuang Xuan Zhuang Xuan Zhuang Jinchun Xing Jinchun Xing Jinchun Xing |
| author_facet | Jiaxuan Qin Jiaxuan Qin Jiaxuan Qin Yufeng Yang Yufeng Yang Yufeng Yang Xuan Zhuang Xuan Zhuang Xuan Zhuang Jinchun Xing Jinchun Xing Jinchun Xing |
| author_sort | Jiaxuan Qin |
| collection | DOAJ |
| description | Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis.Methods: Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs.Results: Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup.Conclusions: Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis. |
| first_indexed | 2024-12-11T21:02:52Z |
| format | Article |
| id | doaj.art-381a41ad7b38495aa64372a020166109 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T21:02:52Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-381a41ad7b38495aa64372a0201661092022-12-22T00:50:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-01-011110.3389/fendo.2020.00002509275Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-AnalysisJiaxuan Qin0Jiaxuan Qin1Jiaxuan Qin2Yufeng Yang3Yufeng Yang4Yufeng Yang5Xuan Zhuang6Xuan Zhuang7Xuan Zhuang8Jinchun Xing9Jinchun Xing10Jinchun Xing11Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaCenter of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaThe Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaCenter of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaThe Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaCenter of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaThe Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaCenter of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaThe Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaBackground: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis.Methods: Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs.Results: Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup.Conclusions: Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.https://www.frontiersin.org/article/10.3389/fendo.2020.00002/fullBAK1rs210138single nucleotide polymorphismstesticular germ cell tumorsmeta-analysis |
| spellingShingle | Jiaxuan Qin Jiaxuan Qin Jiaxuan Qin Yufeng Yang Yufeng Yang Yufeng Yang Xuan Zhuang Xuan Zhuang Xuan Zhuang Jinchun Xing Jinchun Xing Jinchun Xing Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis Frontiers in Endocrinology BAK1 rs210138 single nucleotide polymorphisms testicular germ cell tumors meta-analysis |
| title | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis |
| title_full | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis |
| title_fullStr | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis |
| title_short | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis |
| title_sort | association between bak1 gene rs210138 polymorphisms and testicular germ cell tumors a systematic review and meta analysis |
| topic | BAK1 rs210138 single nucleotide polymorphisms testicular germ cell tumors meta-analysis |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00002/full |
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