Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions
Objective To investigate association between CCL17, CCL22 and substance P (SP) and pruritus in patients with bullous pemphigoid (BP) pruritus. Methods Clinical data of 30 patients and 10 healthy controls were collected. Pruritus was assessed by the Numerical Rating Scale (NRS). Expressions of CCL17,...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2022-12-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.06.005 |
| _version_ | 1797732577055866880 |
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| author | Manman ZHANG Xiaohong LI Yan LIU |
| author_facet | Manman ZHANG Xiaohong LI Yan LIU |
| author_sort | Manman ZHANG |
| collection | DOAJ |
| description | Objective To investigate association between CCL17, CCL22 and substance P (SP) and pruritus in patients with bullous pemphigoid (BP) pruritus. Methods Clinical data of 30 patients and 10 healthy controls were collected. Pruritus was assessed by the Numerical Rating Scale (NRS). Expressions of CCL17, CCL22, and SP in the epidermis and dermis of the BP group and control group was detected by immunohistochemistry, and in the BP group to determine whether there is a correlation with pruritus. Results Higher expressions of CCL17, CCL22, and SP in the epidermis and dermis of patients with BP were found when compared to those in the control group (P<0.05). CCL17 was positively correlated with NRS score in patients with BP patients (r=0.79, P<0.05; r=0.51, P<0.05); CCL22 in the epidermis and substance P in thedermis positively correlated with NRS score (r=0.47, P<0.05; r=0.43, P<0.05). Conclusion CCL17 in epidermis and dermis, CCL22 in epidermis and SP in dermis positively correlate with the degree of pruritus in BP patients. |
| first_indexed | 2024-03-12T12:16:31Z |
| format | Article |
| id | doaj.art-381b72b5c0234b6c9122305aabe09ceb |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-12T12:16:31Z |
| publishDate | 2022-12-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-381b72b5c0234b6c9122305aabe09ceb2023-08-30T11:38:54Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682022-12-0129651852510.3969/j.issn.1674-8468.2022.06.005Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesionsManman ZHANGXiaohong LIYan LIUObjective To investigate association between CCL17, CCL22 and substance P (SP) and pruritus in patients with bullous pemphigoid (BP) pruritus. Methods Clinical data of 30 patients and 10 healthy controls were collected. Pruritus was assessed by the Numerical Rating Scale (NRS). Expressions of CCL17, CCL22, and SP in the epidermis and dermis of the BP group and control group was detected by immunohistochemistry, and in the BP group to determine whether there is a correlation with pruritus. Results Higher expressions of CCL17, CCL22, and SP in the epidermis and dermis of patients with BP were found when compared to those in the control group (P<0.05). CCL17 was positively correlated with NRS score in patients with BP patients (r=0.79, P<0.05; r=0.51, P<0.05); CCL22 in the epidermis and substance P in thedermis positively correlated with NRS score (r=0.47, P<0.05; r=0.43, P<0.05). Conclusion CCL17 in epidermis and dermis, CCL22 in epidermis and SP in dermis positively correlate with the degree of pruritus in BP patients.http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.06.005bullous pemphigoidccl17ccl22substance ppruritus |
| spellingShingle | Manman ZHANG Xiaohong LI Yan LIU Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions Pifu-xingbing zhenliaoxue zazhi bullous pemphigoid ccl17 ccl22 substance p pruritus |
| title | Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions |
| title_full | Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions |
| title_fullStr | Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions |
| title_full_unstemmed | Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions |
| title_short | Positive association between pruritus and high expression of CCL17, CCL22 and substance P in bullous pemphigoid lesions |
| title_sort | positive association between pruritus and high expression of ccl17 ccl22 and substance p in bullous pemphigoid lesions |
| topic | bullous pemphigoid ccl17 ccl22 substance p pruritus |
| url | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.06.005 |
| work_keys_str_mv | AT manmanzhang positiveassociationbetweenpruritusandhighexpressionofccl17ccl22andsubstancepinbullouspemphigoidlesions AT xiaohongli positiveassociationbetweenpruritusandhighexpressionofccl17ccl22andsubstancepinbullouspemphigoidlesions AT yanliu positiveassociationbetweenpruritusandhighexpressionofccl17ccl22andsubstancepinbullouspemphigoidlesions |