Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment
AbstractPurpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative import...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2304020 |
| _version_ | 1797355134116691968 |
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| author | Steven R. Feldman Jacob P. Thyssen Marco Boeri Robert Gerber Maureen P. Neary Amy Cha Brett Hauber Joseph C. Cappelleri Jason Xenakis Colton Leach Joshua Zeichner |
| author_facet | Steven R. Feldman Jacob P. Thyssen Marco Boeri Robert Gerber Maureen P. Neary Amy Cha Brett Hauber Joseph C. Cappelleri Jason Xenakis Colton Leach Joshua Zeichner |
| author_sort | Steven R. Feldman |
| collection | DOAJ |
| description | AbstractPurpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative importance (CRI) of attributes of topical treatments for MM AD among adult and adolescent patients and caregivers of children with MM AD.Materials and methods: A discrete-choice experiment (DCE) survey was administered to US adults and adolescents with MM AD and caregivers of children with MM AD. Each choice task comprised 2 hypothetical topical treatments characterized by efficacy, adverse events, vehicle, and application frequency. Data were analyzed using a random-parameters logit model to calculate the CRI of each attribute.Results and conclusions: 300 adults, 331 adolescents, and 330 caregivers completed the DCE. Avoiding changes in skin color (CRI 29.0) and time until itch improves (26.6) were most important to adults, followed by time until clear/almost clear skin (17.8). Application frequency (3.0) did not have a statistically significant impact on adults’ choices. Adolescents were less concerned about changes in skin color than adults or caregivers; caregivers were less concerned about time until clear/almost clear skin than patients. Physicians should consider age-relevant aspects of preferences in treatment discussions with patients and caregivers. |
| first_indexed | 2024-03-08T14:06:51Z |
| format | Article |
| id | doaj.art-381c24a10916409ba5aff352aa5817bc |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-08T14:06:51Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-381c24a10916409ba5aff352aa5817bc2024-01-15T07:08:30ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2304020Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experimentSteven R. Feldman0Jacob P. Thyssen1Marco Boeri2Robert Gerber3Maureen P. Neary4Amy Cha5Brett Hauber6Joseph C. Cappelleri7Jason Xenakis8Colton Leach9Joshua Zeichner10Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USABispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkRTI Health Solutions, Belfast, UKPfizer Inc, Groton, CT, USAPfizer Inc, Collegeville, PA, USAPfizer Inc, New York, NY, USAPfizer Inc, New York, NY, USAPfizer Inc, Groton, CT, USAPfizer Inc, New York, NY, USARTI Health Solutions, NC, USADepartment of Dermatology, Mount Sinai Hospital, New York, NY, USAAbstractPurpose: Topical treatments for mild-to-moderate (MM) atopic dermatitis (AD) include emollients, corticosteroids, calcineurin inhibitors, a Janus kinase inhibitor, and a phosphodiesterase 4 inhibitor, which differ in multiple ways. This study aimed to quantify the conditional relative importance (CRI) of attributes of topical treatments for MM AD among adult and adolescent patients and caregivers of children with MM AD.Materials and methods: A discrete-choice experiment (DCE) survey was administered to US adults and adolescents with MM AD and caregivers of children with MM AD. Each choice task comprised 2 hypothetical topical treatments characterized by efficacy, adverse events, vehicle, and application frequency. Data were analyzed using a random-parameters logit model to calculate the CRI of each attribute.Results and conclusions: 300 adults, 331 adolescents, and 330 caregivers completed the DCE. Avoiding changes in skin color (CRI 29.0) and time until itch improves (26.6) were most important to adults, followed by time until clear/almost clear skin (17.8). Application frequency (3.0) did not have a statistically significant impact on adults’ choices. Adolescents were less concerned about changes in skin color than adults or caregivers; caregivers were less concerned about time until clear/almost clear skin than patients. Physicians should consider age-relevant aspects of preferences in treatment discussions with patients and caregivers.https://www.tandfonline.com/doi/10.1080/09546634.2024.2304020Atopic dermatitispreferencespatientcaregiverdiscrete-choice experiment |
| spellingShingle | Steven R. Feldman Jacob P. Thyssen Marco Boeri Robert Gerber Maureen P. Neary Amy Cha Brett Hauber Joseph C. Cappelleri Jason Xenakis Colton Leach Joshua Zeichner Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment Journal of Dermatological Treatment Atopic dermatitis preferences patient caregiver discrete-choice experiment |
| title | Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment |
| title_full | Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment |
| title_fullStr | Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment |
| title_full_unstemmed | Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment |
| title_short | Adult, adolescent, and caregiver preferences for attributes of topical treatments for mild-to-moderate atopic dermatitis: a discrete-choice experiment |
| title_sort | adult adolescent and caregiver preferences for attributes of topical treatments for mild to moderate atopic dermatitis a discrete choice experiment |
| topic | Atopic dermatitis preferences patient caregiver discrete-choice experiment |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2304020 |
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