Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning
In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced mi...
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MDPI AG
2023-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/8/2146 |
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| author | Jianfeng Zhou Liangzhe Wang Wenjian Gong Bo Wang Deng-Guang Yu Yuanjie Zhu |
| author_facet | Jianfeng Zhou Liangzhe Wang Wenjian Gong Bo Wang Deng-Guang Yu Yuanjie Zhu |
| author_sort | Jianfeng Zhou |
| collection | DOAJ |
| description | In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were applied to the development of a new type of pharmaceutical formulation, aiming to achieve rapid hemostasis, pain relief, and antimicrobial properties. Briefly, an approach combining a electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent was employed to fabricate a novel beaded nanofiber structure (BNS), consisting of micrometer-sized particles distributed on a nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) particles were prepared using the solution electrospraying process. Subsequently, these particles were suspended in a co-solvent solution containing ciprofloxacin (CIP) and hydrophilic polymer polyvinylpyrrolidone (PVP) and electrospun into hybrid structural microfibers using a handheld electrospinning device, forming the EHDA product E3. The fiber-beaded composite morphology of E3 was confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis revealed the amorphous state of CIP in the BNS membrane due to the good compatibility between CIP and PVP. The rapid dissolution experiment revealed that E3 exhibits fast disintegration properties and promotes the dissolution of CIP. Moreover, in vitro drug release study demonstrated the complete release of CIP within 1 min. Antibacterial assays showed a significant reduction in the number of adhered bacteria on the BNS, indicating excellent antibacterial performance. Compared with the traditional YB powders consisting of Chinese herbs, the BNS showed a series of advantages for potential wound dressing. These advantages include an improved antibacterial effect, a sustained release of active ingredients from YB, and a convenient wound covering application, which were resulted from the integration of Chinese herbs and Western medicine. This study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines from the combination of herbal medicines and Western medicines. |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T00:06:19Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-381e554e5c8744238f8ff6492176d6d72023-11-19T00:20:03ZengMDPI AGBiomedicines2227-90592023-07-01118214610.3390/biomedicines11082146Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld ElectrospinningJianfeng Zhou0Liangzhe Wang1Wenjian Gong2Bo Wang3Deng-Guang Yu4Yuanjie Zhu5School of Materials & Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaDepartment of Dermatology, Naval Special Medical Center, Naval Medical University, Shanghai 200052, ChinaSchool of Materials & Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaDepartment of Dermatology, Naval Special Medical Center, Naval Medical University, Shanghai 200052, ChinaSchool of Materials & Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaDepartment of Dermatology, Naval Special Medical Center, Naval Medical University, Shanghai 200052, ChinaIn this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were applied to the development of a new type of pharmaceutical formulation, aiming to achieve rapid hemostasis, pain relief, and antimicrobial properties. Briefly, an approach combining a electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent was employed to fabricate a novel beaded nanofiber structure (BNS), consisting of micrometer-sized particles distributed on a nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) particles were prepared using the solution electrospraying process. Subsequently, these particles were suspended in a co-solvent solution containing ciprofloxacin (CIP) and hydrophilic polymer polyvinylpyrrolidone (PVP) and electrospun into hybrid structural microfibers using a handheld electrospinning device, forming the EHDA product E3. The fiber-beaded composite morphology of E3 was confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis revealed the amorphous state of CIP in the BNS membrane due to the good compatibility between CIP and PVP. The rapid dissolution experiment revealed that E3 exhibits fast disintegration properties and promotes the dissolution of CIP. Moreover, in vitro drug release study demonstrated the complete release of CIP within 1 min. Antibacterial assays showed a significant reduction in the number of adhered bacteria on the BNS, indicating excellent antibacterial performance. Compared with the traditional YB powders consisting of Chinese herbs, the BNS showed a series of advantages for potential wound dressing. These advantages include an improved antibacterial effect, a sustained release of active ingredients from YB, and a convenient wound covering application, which were resulted from the integration of Chinese herbs and Western medicine. This study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines from the combination of herbal medicines and Western medicines.https://www.mdpi.com/2227-9059/11/8/2146electrospinningelectrosprayingYunnan Baiyaociprofloxacinantimicrobialcombined medicine |
| spellingShingle | Jianfeng Zhou Liangzhe Wang Wenjian Gong Bo Wang Deng-Guang Yu Yuanjie Zhu Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning Biomedicines electrospinning electrospraying Yunnan Baiyao ciprofloxacin antimicrobial combined medicine |
| title | Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning |
| title_full | Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning |
| title_fullStr | Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning |
| title_full_unstemmed | Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning |
| title_short | Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning |
| title_sort | integrating chinese herbs and western medicine for new wound dressings through handheld electrospinning |
| topic | electrospinning electrospraying Yunnan Baiyao ciprofloxacin antimicrobial combined medicine |
| url | https://www.mdpi.com/2227-9059/11/8/2146 |
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