“Targeting Design” of Nanoparticles in Tumor Therapy
Tumor-targeted therapy based on nanoparticles is a popular research direction in the biomedical field. After decades of research and development, both the passive targeting ability of the inherent properties of NPs and the active targeting based on ligand receptor interaction have gained deeper unde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/9/1919 |
| _version_ | 1797483591090831360 |
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| author | Tingting Yang Jingming Zhai Dong Hu Ruyue Yang Guidan Wang Yuanpei Li Gaofeng Liang |
| author_facet | Tingting Yang Jingming Zhai Dong Hu Ruyue Yang Guidan Wang Yuanpei Li Gaofeng Liang |
| author_sort | Tingting Yang |
| collection | DOAJ |
| description | Tumor-targeted therapy based on nanoparticles is a popular research direction in the biomedical field. After decades of research and development, both the passive targeting ability of the inherent properties of NPs and the active targeting based on ligand receptor interaction have gained deeper understanding. Unfortunately, most targeted delivery strategies are still in the preclinical trial stage, so it is necessary to further study the biological fate of particles in vivo and the interaction mechanism with tumors. This article reviews different targeted delivery strategies based on NPs, and focuses on the physical and chemical properties of NPs (size, morphology, surface and intrinsic properties), ligands (binding number/force, activity and species) and receptors (endocytosis, distribution and recycling) and other factors that affect particle targeting. The limitations and solutions of these factors are further discussed, and a variety of new targeting schemes are introduced, hoping to provide guidance for future targeting design and achieve the purpose of rapid transformation of targeted particles into clinical application. |
| first_indexed | 2024-03-09T22:49:13Z |
| format | Article |
| id | doaj.art-381e6311f5e142a79f3d2f4ccf553c2d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:49:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-381e6311f5e142a79f3d2f4ccf553c2d2023-11-23T18:22:59ZengMDPI AGPharmaceutics1999-49232022-09-01149191910.3390/pharmaceutics14091919“Targeting Design” of Nanoparticles in Tumor TherapyTingting Yang0Jingming Zhai1Dong Hu2Ruyue Yang3Guidan Wang4Yuanpei Li5Gaofeng Liang6School of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaDepartment of General Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science & Technology, Luoyang 471003, ChinaSchool of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaSchool of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaSchool of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaSchool of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaSchool of Basic Medical Sciences, Henan University of Science & Technology, Luoyang 471023, ChinaTumor-targeted therapy based on nanoparticles is a popular research direction in the biomedical field. After decades of research and development, both the passive targeting ability of the inherent properties of NPs and the active targeting based on ligand receptor interaction have gained deeper understanding. Unfortunately, most targeted delivery strategies are still in the preclinical trial stage, so it is necessary to further study the biological fate of particles in vivo and the interaction mechanism with tumors. This article reviews different targeted delivery strategies based on NPs, and focuses on the physical and chemical properties of NPs (size, morphology, surface and intrinsic properties), ligands (binding number/force, activity and species) and receptors (endocytosis, distribution and recycling) and other factors that affect particle targeting. The limitations and solutions of these factors are further discussed, and a variety of new targeting schemes are introduced, hoping to provide guidance for future targeting design and achieve the purpose of rapid transformation of targeted particles into clinical application.https://www.mdpi.com/1999-4923/14/9/1919nanoparticlesdrug deliverytargeted transportationcancer therapyapplication |
| spellingShingle | Tingting Yang Jingming Zhai Dong Hu Ruyue Yang Guidan Wang Yuanpei Li Gaofeng Liang “Targeting Design” of Nanoparticles in Tumor Therapy Pharmaceutics nanoparticles drug delivery targeted transportation cancer therapy application |
| title | “Targeting Design” of Nanoparticles in Tumor Therapy |
| title_full | “Targeting Design” of Nanoparticles in Tumor Therapy |
| title_fullStr | “Targeting Design” of Nanoparticles in Tumor Therapy |
| title_full_unstemmed | “Targeting Design” of Nanoparticles in Tumor Therapy |
| title_short | “Targeting Design” of Nanoparticles in Tumor Therapy |
| title_sort | targeting design of nanoparticles in tumor therapy |
| topic | nanoparticles drug delivery targeted transportation cancer therapy application |
| url | https://www.mdpi.com/1999-4923/14/9/1919 |
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