Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model
Menopause is a significant phase in a woman’s life. Menopausal symptoms can affect overall well-being and quality of life. Conventionally, hormone replacement therapy (HRT) is used to alleviate menopausal symptoms; however, depending on the conditions, HRT may lead to side effects, necessitating the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/20/4485 |
| _version_ | 1797572616415870976 |
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| author | Sun-Hee Lee Tae-Joong Lim Eun Ju Yun Kyoung Heon Kim Sanghyun Lim |
| author_facet | Sun-Hee Lee Tae-Joong Lim Eun Ju Yun Kyoung Heon Kim Sanghyun Lim |
| author_sort | Sun-Hee Lee |
| collection | DOAJ |
| description | Menopause is a significant phase in a woman’s life. Menopausal symptoms can affect overall well-being and quality of life. Conventionally, hormone replacement therapy (HRT) is used to alleviate menopausal symptoms; however, depending on the conditions, HRT may lead to side effects, necessitating the exploration of alternative therapies with fewer side effects. In this study, we investigated the effects of a combination of soybean germ extract (S30) containing 30% (<i>w</i>/<i>w</i>) isoflavone and a probiotic, <i>Lactobacillus gasseri</i> (LGA1), on menopausal conditions in an ovariectomized (OVX) rat model. We evaluated the impact of S30+LGA on body weight, estrogen markers, uterine and bone health, vascular markers, and neurotransmitter levels. The results revealed that treatment with S30+LGA1 significantly improved body weight and uterine and bone health. Moreover, S30+LGA1 demonstrated promising effects on lipid profile, liver function, and vascular markers and positively impacted serotonin and norepinephrine levels, indicating potential mood-enhancing effects. In conclusion, S30+LGA1, possessing anti-menopausal effects in vitro and in vivo, can be recommended as a soy-based diet, which offers various health benefits, especially for menopausal women. |
| first_indexed | 2024-03-10T20:59:26Z |
| format | Article |
| id | doaj.art-381ef9d337404e71aadf874d99830f0f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:59:26Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-381ef9d337404e71aadf874d99830f0f2023-11-19T17:39:38ZengMDPI AGNutrients2072-66432023-10-011520448510.3390/nu15204485Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat ModelSun-Hee Lee0Tae-Joong Lim1Eun Ju Yun2Kyoung Heon Kim3Sanghyun Lim4Department of Biotechnology, Graduate School, Korea University, Seoul 02841, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo 10003, Republic of KoreaDivision of Biotechnology, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Biotechnology, Graduate School, Korea University, Seoul 02841, Republic of KoreaR&D Center, Cell Biotech Co., Ltd., Gimpo 10003, Republic of KoreaMenopause is a significant phase in a woman’s life. Menopausal symptoms can affect overall well-being and quality of life. Conventionally, hormone replacement therapy (HRT) is used to alleviate menopausal symptoms; however, depending on the conditions, HRT may lead to side effects, necessitating the exploration of alternative therapies with fewer side effects. In this study, we investigated the effects of a combination of soybean germ extract (S30) containing 30% (<i>w</i>/<i>w</i>) isoflavone and a probiotic, <i>Lactobacillus gasseri</i> (LGA1), on menopausal conditions in an ovariectomized (OVX) rat model. We evaluated the impact of S30+LGA on body weight, estrogen markers, uterine and bone health, vascular markers, and neurotransmitter levels. The results revealed that treatment with S30+LGA1 significantly improved body weight and uterine and bone health. Moreover, S30+LGA1 demonstrated promising effects on lipid profile, liver function, and vascular markers and positively impacted serotonin and norepinephrine levels, indicating potential mood-enhancing effects. In conclusion, S30+LGA1, possessing anti-menopausal effects in vitro and in vivo, can be recommended as a soy-based diet, which offers various health benefits, especially for menopausal women.https://www.mdpi.com/2072-6643/15/20/4485menopausesoybean germ extractisoflavoneprobioticslactic acid bacteriaaglycone |
| spellingShingle | Sun-Hee Lee Tae-Joong Lim Eun Ju Yun Kyoung Heon Kim Sanghyun Lim Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model Nutrients menopause soybean germ extract isoflavone probiotics lactic acid bacteria aglycone |
| title | Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model |
| title_full | Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model |
| title_fullStr | Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model |
| title_full_unstemmed | Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model |
| title_short | Anti-Menopausal Effect of Soybean Germ Extract and <i>Lactobacillus gasseri</i> in the Ovariectomized Rat Model |
| title_sort | anti menopausal effect of soybean germ extract and i lactobacillus gasseri i in the ovariectomized rat model |
| topic | menopause soybean germ extract isoflavone probiotics lactic acid bacteria aglycone |
| url | https://www.mdpi.com/2072-6643/15/20/4485 |
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