Sepsis-Associated Acute Kidney Injury
Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute kidney injury, with a six- to eightfold increase...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-08-01
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| Series: | Intensive Care Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44231-023-00049-0 |
| _version_ | 1797397937089675264 |
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| author | Dong Wang Tongwen Sun Zhangsuo Liu |
| author_facet | Dong Wang Tongwen Sun Zhangsuo Liu |
| author_sort | Dong Wang |
| collection | DOAJ |
| description | Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute kidney injury, with a six- to eightfold increase in mortality. Growing evidences elucidate pathophysiological mechanisms, biomarkers, and response to therapy of sepsis-associated acute kidney injury (S-AKI). However, there is still a lack of effective and specific interventions for the treatment of S-AKI. This review summarizes the relevant evidence and provides an overview of the current understanding of S-AKI, focusing on pathophysiology, diagnosis, biomarkers, and therapeutic approaches. |
| first_indexed | 2024-03-09T01:18:24Z |
| format | Article |
| id | doaj.art-381fad8626ee4bebae40f875046420d5 |
| institution | Directory Open Access Journal |
| issn | 2666-9862 |
| language | English |
| last_indexed | 2024-03-09T01:18:24Z |
| publishDate | 2023-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Intensive Care Research |
| spelling | doaj.art-381fad8626ee4bebae40f875046420d52023-12-10T12:20:21ZengSpringerIntensive Care Research2666-98622023-08-013425125810.1007/s44231-023-00049-0Sepsis-Associated Acute Kidney InjuryDong Wang0Tongwen Sun1Zhangsuo Liu2General Intensive Care Unit, The First Affiliated Hospital of Zhengzhou UniversityGeneral Intensive Care Unit, The First Affiliated Hospital of Zhengzhou UniversityTraditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou UniversityAbstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute kidney injury, with a six- to eightfold increase in mortality. Growing evidences elucidate pathophysiological mechanisms, biomarkers, and response to therapy of sepsis-associated acute kidney injury (S-AKI). However, there is still a lack of effective and specific interventions for the treatment of S-AKI. This review summarizes the relevant evidence and provides an overview of the current understanding of S-AKI, focusing on pathophysiology, diagnosis, biomarkers, and therapeutic approaches.https://doi.org/10.1007/s44231-023-00049-0SepsisSepsis-associated acute lung injuryEpidemiologyPathophysiologyTreatmentPrevention |
| spellingShingle | Dong Wang Tongwen Sun Zhangsuo Liu Sepsis-Associated Acute Kidney Injury Intensive Care Research Sepsis Sepsis-associated acute lung injury Epidemiology Pathophysiology Treatment Prevention |
| title | Sepsis-Associated Acute Kidney Injury |
| title_full | Sepsis-Associated Acute Kidney Injury |
| title_fullStr | Sepsis-Associated Acute Kidney Injury |
| title_full_unstemmed | Sepsis-Associated Acute Kidney Injury |
| title_short | Sepsis-Associated Acute Kidney Injury |
| title_sort | sepsis associated acute kidney injury |
| topic | Sepsis Sepsis-associated acute lung injury Epidemiology Pathophysiology Treatment Prevention |
| url | https://doi.org/10.1007/s44231-023-00049-0 |
| work_keys_str_mv | AT dongwang sepsisassociatedacutekidneyinjury AT tongwensun sepsisassociatedacutekidneyinjury AT zhangsuoliu sepsisassociatedacutekidneyinjury |