An unusual occurrence of repeated single allele variation on Y-STR locus DYS458
Six brothers were accused of gagging and raping a woman. A single male Y-STR profile was obtained from vaginal smear swab and clothes of the victim, which did not match with the DNA profile of the accused brothers. As a reference point, the blood sample of their father (aged 87 years) was also analy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-09-01
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| Series: | Egyptian Journal of Forensic Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090536X1500043X |
| _version_ | 1819179928589959168 |
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| author | Pankaj Shrivastava Veena Ben Trivedi Toshi Jain Mehmood Ali |
| author_facet | Pankaj Shrivastava Veena Ben Trivedi Toshi Jain Mehmood Ali |
| author_sort | Pankaj Shrivastava |
| collection | DOAJ |
| description | Six brothers were accused of gagging and raping a woman. A single male Y-STR profile was obtained from vaginal smear swab and clothes of the victim, which did not match with the DNA profile of the accused brothers. As a reference point, the blood sample of their father (aged 87 years) was also analyzed with the same kit. The Y-STR haplotype of all six brothers was found to be the same as that of their father except at locus DYS458. At this locus, while the eldest, second and fourth siblings share allele 18 with their father, a loss of one repeat (allele 17 instead of 18) is observed in the third son while fifth and sixth siblings have allele 19 representing a gain of one repeat. Thus, two changes viz. a gain (twice) and loss of one repeat at this locus in one generation is both interesting and unusual. |
| first_indexed | 2024-12-22T22:06:14Z |
| format | Article |
| id | doaj.art-38232034c5564300bb8c95fda8d577a2 |
| institution | Directory Open Access Journal |
| issn | 2090-536X |
| language | English |
| last_indexed | 2024-12-22T22:06:14Z |
| publishDate | 2016-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Forensic Sciences |
| spelling | doaj.art-38232034c5564300bb8c95fda8d577a22022-12-21T18:10:58ZengSpringerOpenEgyptian Journal of Forensic Sciences2090-536X2016-09-016328929110.1016/j.ejfs.2015.05.003An unusual occurrence of repeated single allele variation on Y-STR locus DYS458Pankaj ShrivastavaVeena Ben TrivediToshi JainMehmood AliSix brothers were accused of gagging and raping a woman. A single male Y-STR profile was obtained from vaginal smear swab and clothes of the victim, which did not match with the DNA profile of the accused brothers. As a reference point, the blood sample of their father (aged 87 years) was also analyzed with the same kit. The Y-STR haplotype of all six brothers was found to be the same as that of their father except at locus DYS458. At this locus, while the eldest, second and fourth siblings share allele 18 with their father, a loss of one repeat (allele 17 instead of 18) is observed in the third son while fifth and sixth siblings have allele 19 representing a gain of one repeat. Thus, two changes viz. a gain (twice) and loss of one repeat at this locus in one generation is both interesting and unusual.http://www.sciencedirect.com/science/article/pii/S2090536X1500043XForensic scienceDNA typingY-STRMutationDYS458Allele variation |
| spellingShingle | Pankaj Shrivastava Veena Ben Trivedi Toshi Jain Mehmood Ali An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 Egyptian Journal of Forensic Sciences Forensic science DNA typing Y-STR Mutation DYS458 Allele variation |
| title | An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 |
| title_full | An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 |
| title_fullStr | An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 |
| title_full_unstemmed | An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 |
| title_short | An unusual occurrence of repeated single allele variation on Y-STR locus DYS458 |
| title_sort | unusual occurrence of repeated single allele variation on y str locus dys458 |
| topic | Forensic science DNA typing Y-STR Mutation DYS458 Allele variation |
| url | http://www.sciencedirect.com/science/article/pii/S2090536X1500043X |
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