Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery
Hierarchical zeolites are aluminosilicates with a crystal structure, which next to the micropores possess secondary porosity in the range of mesopores and/or small macropores. Due to their ordered structure and additional secondary porosity, they have aroused great interest among scientists in recen...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/535 |
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| author | Agata Wawrzyńczak Izabela Nowak Natalia Woźniak Jagoda Chudzińska Agnieszka Feliczak-Guzik |
| author_facet | Agata Wawrzyńczak Izabela Nowak Natalia Woźniak Jagoda Chudzińska Agnieszka Feliczak-Guzik |
| author_sort | Agata Wawrzyńczak |
| collection | DOAJ |
| description | Hierarchical zeolites are aluminosilicates with a crystal structure, which next to the micropores possess secondary porosity in the range of mesopores and/or small macropores. Due to their ordered structure and additional secondary porosity, they have aroused great interest among scientists in recent years. Therefore, the present work concerns the synthesis and characterization of hierarchical zeolites with secondary mesoporosity, based on commercial zeolites such as MFI (ZSM-5), BEA (β) and FAU (Y), and modified with polysaccharides such as inulin, hyaluronic acid, and heparin. All materials were characterized by various analytical techniques and applied as a platform for delivery of selected drug molecules. On the basis of X-ray diffraction (presence of reflections in the 2θ angle range of 1.5–2.5°) and low-temperature nitrogen sorption isotherms (mixture of isotherms of I and IV type) additional secondary porosity was found in the mesopore range. Additional tests were also conducted to determine the possibility of loading selected molecules with biological activity into the aforementioned materials and then releasing them in the therapeutic process. Molecules with different therapeutic options were selected for testing, namely ibuprofen, curcumin, and ferulic acid with anti-inflammatory, potentially anticancer, antioxidant, and skin discoloration activities, respectively. Preliminary studies have confirmed the possibility of using hierarchical zeolites as potential carriers for bioactive molecules, as the loading percentage of active substances ranged from 39–79% and cumulative release for ibuprofen reached almost 100% after 8 h of testing. |
| first_indexed | 2024-03-11T08:16:41Z |
| format | Article |
| id | doaj.art-3823c25689ef4510a3891137487da481 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:16:41Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3823c25689ef4510a3891137487da4812023-11-16T22:41:15ZengMDPI AGPharmaceutics1999-49232023-02-0115253510.3390/pharmaceutics15020535Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug DeliveryAgata Wawrzyńczak0Izabela Nowak1Natalia Woźniak2Jagoda Chudzińska3Agnieszka Feliczak-Guzik4Faculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, PolandHierarchical zeolites are aluminosilicates with a crystal structure, which next to the micropores possess secondary porosity in the range of mesopores and/or small macropores. Due to their ordered structure and additional secondary porosity, they have aroused great interest among scientists in recent years. Therefore, the present work concerns the synthesis and characterization of hierarchical zeolites with secondary mesoporosity, based on commercial zeolites such as MFI (ZSM-5), BEA (β) and FAU (Y), and modified with polysaccharides such as inulin, hyaluronic acid, and heparin. All materials were characterized by various analytical techniques and applied as a platform for delivery of selected drug molecules. On the basis of X-ray diffraction (presence of reflections in the 2θ angle range of 1.5–2.5°) and low-temperature nitrogen sorption isotherms (mixture of isotherms of I and IV type) additional secondary porosity was found in the mesopore range. Additional tests were also conducted to determine the possibility of loading selected molecules with biological activity into the aforementioned materials and then releasing them in the therapeutic process. Molecules with different therapeutic options were selected for testing, namely ibuprofen, curcumin, and ferulic acid with anti-inflammatory, potentially anticancer, antioxidant, and skin discoloration activities, respectively. Preliminary studies have confirmed the possibility of using hierarchical zeolites as potential carriers for bioactive molecules, as the loading percentage of active substances ranged from 39–79% and cumulative release for ibuprofen reached almost 100% after 8 h of testing.https://www.mdpi.com/1999-4923/15/2/535hierarchical zeolitesmesoporositymodificationpolysaccharidesibuprofencurcumin |
| spellingShingle | Agata Wawrzyńczak Izabela Nowak Natalia Woźniak Jagoda Chudzińska Agnieszka Feliczak-Guzik Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery Pharmaceutics hierarchical zeolites mesoporosity modification polysaccharides ibuprofen curcumin |
| title | Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery |
| title_full | Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery |
| title_fullStr | Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery |
| title_full_unstemmed | Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery |
| title_short | Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery |
| title_sort | synthesis and characterization of hierarchical zeolites modified with polysaccharides and its potential role as a platform for drug delivery |
| topic | hierarchical zeolites mesoporosity modification polysaccharides ibuprofen curcumin |
| url | https://www.mdpi.com/1999-4923/15/2/535 |
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