Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells

Abstract Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms. Treatment of late-stage HCC relies heavily on chemotherapeutics, many of which target cellular energy metabolism. A key platform for test...

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Bibliographic Details
Main Authors: Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman, P. Darrell Neufer
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer & Metabolism
Subjects:
Cancer
Mitochondria
Oxidative phosphorylation
Glycolysis
Confocal microscopy
Oroboros
Online Access:https://doi.org/10.1186/s40170-021-00241-0

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