Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis
The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37379-y |
| _version_ | 1797853706886053888 |
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| author | Hong Sheng Quah Elaine Yiqun Cao Lisda Suteja Constance H. Li Hui Sun Leong Fui Teen Chong Shilpi Gupta Camille Arcinas John F. Ouyang Vivian Ang Teja Celhar Yunqian Zhao Hui Chen Tay Jerry Chan Takeshi Takahashi Daniel S. W. Tan Subhra K. Biswas Owen J. L. Rackham N. Gopalakrishna Iyer |
| author_facet | Hong Sheng Quah Elaine Yiqun Cao Lisda Suteja Constance H. Li Hui Sun Leong Fui Teen Chong Shilpi Gupta Camille Arcinas John F. Ouyang Vivian Ang Teja Celhar Yunqian Zhao Hui Chen Tay Jerry Chan Takeshi Takahashi Daniel S. W. Tan Subhra K. Biswas Owen J. L. Rackham N. Gopalakrishna Iyer |
| author_sort | Hong Sheng Quah |
| collection | DOAJ |
| description | The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis. |
| first_indexed | 2024-04-09T19:55:03Z |
| format | Article |
| id | doaj.art-38255f69fa6848db9cd30e34bbfaa608 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:55:03Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-38255f69fa6848db9cd30e34bbfaa6082023-04-03T05:32:11ZengNature PortfolioNature Communications2041-17232023-03-0114111910.1038/s41467-023-37379-ySingle cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasisHong Sheng Quah0Elaine Yiqun Cao1Lisda Suteja2Constance H. Li3Hui Sun Leong4Fui Teen Chong5Shilpi Gupta6Camille Arcinas7John F. Ouyang8Vivian Ang9Teja Celhar10Yunqian Zhao11Hui Chen Tay12Jerry Chan13Takeshi Takahashi14Daniel S. W. Tan15Subhra K. Biswas16Owen J. L. Rackham17N. Gopalakrishna Iyer18Cancer Therapeutics Research Laboratory, National Cancer CentreProgram in Cardiovascular and Metabolic Disorders, Duke-NUS Medical SchoolCancer Therapeutics Research Laboratory, National Cancer CentreCancer Therapeutics Research Laboratory, National Cancer CentreCancer Therapeutics Research Laboratory, National Cancer CentreCancer Therapeutics Research Laboratory, National Cancer CentreSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)Cancer Therapeutics Research Laboratory, National Cancer CentreProgram in Cardiovascular and Metabolic Disorders, Duke-NUS Medical SchoolSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Department of Reproductive Medicine, KK Women’s and Children’s HospitalLaboratory Animal Research Department, Central Institute for Experimental Animals (CIEA)Cancer Therapeutics Research Laboratory, National Cancer CentreSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical SchoolCancer Therapeutics Research Laboratory, National Cancer CentreThe molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis.https://doi.org/10.1038/s41467-023-37379-y |
| spellingShingle | Hong Sheng Quah Elaine Yiqun Cao Lisda Suteja Constance H. Li Hui Sun Leong Fui Teen Chong Shilpi Gupta Camille Arcinas John F. Ouyang Vivian Ang Teja Celhar Yunqian Zhao Hui Chen Tay Jerry Chan Takeshi Takahashi Daniel S. W. Tan Subhra K. Biswas Owen J. L. Rackham N. Gopalakrishna Iyer Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis Nature Communications |
| title | Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| title_full | Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| title_fullStr | Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| title_full_unstemmed | Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| title_short | Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| title_sort | single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis |
| url | https://doi.org/10.1038/s41467-023-37379-y |
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