Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L.
Some of the most effective anticancer compounds are still derived from plants since the chemical synthesis of chiral molecules is not economically efficient. Rapid discovery of lead compounds with pronounced biological activity is essential for the successful development of novel drug candidates. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/9/267 |
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| author | Iliana Ionkova Aleksandar Shkondrov Yancho Zarev Ekaterina Kozuharova Ilina Krasteva |
| author_facet | Iliana Ionkova Aleksandar Shkondrov Yancho Zarev Ekaterina Kozuharova Ilina Krasteva |
| author_sort | Iliana Ionkova |
| collection | DOAJ |
| description | Some of the most effective anticancer compounds are still derived from plants since the chemical synthesis of chiral molecules is not economically efficient. Rapid discovery of lead compounds with pronounced biological activity is essential for the successful development of novel drug candidates. This work aims to present the chemical diversity of antitumor bioactive compounds and biotechnological approaches as alternative production and sustainable plant biodiversity conservation. <i>Astragalus</i> spp., (Fabaceae) and <i>Gloriosa</i> spp. (Liliaceae) are selected as research objects within this review because they are known for their anticancer activity, because they represent two of the largest families respectively in dicots and monocots, and also because many of the medicinally important plants are rare and endangered. We summarized the ethnobotanical data concerning their anticancer application, highlighted the diversity of their secondary metabolites possessing anticancer properties such as saponins, flavonoids, and alkaloids, and revealed the potential of the in vitro cultures as an alternative way of their production. Since the natural supply is limited, it is important to explore the possibility of employing plant cell or organ in vitro cultures for the biotechnological production of these compounds as an alternative. |
| first_indexed | 2024-03-10T00:22:35Z |
| format | Article |
| id | doaj.art-38260933b28643169bebb1937710a21c |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T00:22:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-38260933b28643169bebb1937710a21c2023-11-23T15:39:00ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-08-014493884390410.3390/cimb44090267Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L.Iliana Ionkova0Aleksandar Shkondrov1Yancho Zarev2Ekaterina Kozuharova3Ilina Krasteva4Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaSome of the most effective anticancer compounds are still derived from plants since the chemical synthesis of chiral molecules is not economically efficient. Rapid discovery of lead compounds with pronounced biological activity is essential for the successful development of novel drug candidates. This work aims to present the chemical diversity of antitumor bioactive compounds and biotechnological approaches as alternative production and sustainable plant biodiversity conservation. <i>Astragalus</i> spp., (Fabaceae) and <i>Gloriosa</i> spp. (Liliaceae) are selected as research objects within this review because they are known for their anticancer activity, because they represent two of the largest families respectively in dicots and monocots, and also because many of the medicinally important plants are rare and endangered. We summarized the ethnobotanical data concerning their anticancer application, highlighted the diversity of their secondary metabolites possessing anticancer properties such as saponins, flavonoids, and alkaloids, and revealed the potential of the in vitro cultures as an alternative way of their production. Since the natural supply is limited, it is important to explore the possibility of employing plant cell or organ in vitro cultures for the biotechnological production of these compounds as an alternative.https://www.mdpi.com/1467-3045/44/9/267plant anticancer compoundsin vitro productionsaponinsflavonoidsalkaloids<i>Astragalus</i> |
| spellingShingle | Iliana Ionkova Aleksandar Shkondrov Yancho Zarev Ekaterina Kozuharova Ilina Krasteva Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. Current Issues in Molecular Biology plant anticancer compounds in vitro production saponins flavonoids alkaloids <i>Astragalus</i> |
| title | Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. |
| title_full | Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. |
| title_fullStr | Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. |
| title_full_unstemmed | Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. |
| title_short | Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus <i>Astragalus</i> L. and <i>Gloriosa</i> L. |
| title_sort | anticancer secondary metabolites from ethnopharmacology and identification in native complexes to biotechnological studies in species of genus i astragalus i l and i gloriosa i l |
| topic | plant anticancer compounds in vitro production saponins flavonoids alkaloids <i>Astragalus</i> |
| url | https://www.mdpi.com/1467-3045/44/9/267 |
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