Optimization of a Methodology for Quantification and Removal of Zinc Gives Insights Into the Effect of This Metal on the Stability and Function of the Zinc-Binding Co-chaperone Ydj1

Optimization of a Methodology for Quantification and Removal of Zinc Gives Insights Into the Effect of This Metal on the Stability and Function of the Zinc-Binding Co-chaperone Ydj1

Ydj1, a class B J-protein (Hsp40) in yeast, has two zinc finger domains in each monomer and belongs to an important co-chaperone family that plays crucial roles in cells, such as recognizing and binding partially folded proteins and assisting the Hsp70 chaperone family in protein folding. Yeast cell...

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Bibliographic Details
Main Authors: Jemmyson Romário de Jesus, Annelize Zambon Barbosa Aragão, Marco Aurélio Zezzi Arruda, Carlos H. I. Ramos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Chemistry
Subjects:
ICP-MS
zinc
Hsp40
protein folding and stability
protein structure/function relationship
homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00416/full

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