Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly
A 94-year-old female patient presented with anorexia and left axillar lymphadenopathy on admission. Her past history was angina pectoris at 83 years of age and total gastrectomy due to gastric cancer at 87 years. The family history revealed that her son had had a malignant lymphoma, the histopatholo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-05-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/345572 |
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| author | T. Mizuno M. Ishigaki K. Nakajima T. Matsue M. Fukushima H. Minato N. Nojima Saito Atsushi K. Ishigami H. Atsumi T. Ito M. Iguchi D. Usuda H. Okamura S. Urashima M. Asano A. Fukuda Y. Izumi N. Takekoshi T. Kanda |
| author_facet | T. Mizuno M. Ishigaki K. Nakajima T. Matsue M. Fukushima H. Minato N. Nojima Saito Atsushi K. Ishigami H. Atsumi T. Ito M. Iguchi D. Usuda H. Okamura S. Urashima M. Asano A. Fukuda Y. Izumi N. Takekoshi T. Kanda |
| author_sort | T. Mizuno |
| collection | DOAJ |
| description | A 94-year-old female patient presented with anorexia and left axillar lymphadenopathy on admission. Her past history was angina pectoris at 83 years of age and total gastrectomy due to gastric cancer at 87 years. The family history revealed that her son had had a malignant lymphoma, the histopathological diagnosis of which was diffuse large B-cell lymphoma. A physical examination showed both cervical, axillar, and inguinal lymphadenopathy without tenderness. She had elevated lactate dehydrogenase, ferritin, and soluble interleukin-2 receptor (sIL-2R). Whole-body computed tomography confirmed the cervical, axillary, and inguinal lymphadenopathy. Gallium-68 imaging revealed positive accumulation in these superficial lymph nodes. A right inguinal lymph node biopsy showed features of Epstein-Barr virus-associated lymphoproliferative disorder. Immunohistological studies on this lymph node biopsy showed CD20-positive large cells, CD3-positive small cells, and CD30-partly-positive large cells. In situ hybridization showed Epstein-Barr virus-positive, LMP-partly-positive, and EBNA2-negative cells. She refused chemotherapy as her son had died from hematemesis during chemotherapy. She received intravenous hyperalimentation for 1 month after admission. No palpable lymph nodes were identified by physical examination or computed tomography 3 months after admission, and regression of lactate dehydrogenase, ferritin, and sIL-2R was observed. She recovered from anorexia and was discharged. She died from pneumonia 10 months later after initial symptoms of anorexia. The autopsy showed no superficial lymphadenopathy. |
| first_indexed | 2024-12-21T20:44:15Z |
| format | Article |
| id | doaj.art-3828efbb2f7347e1a94f2680329ff8c8 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-21T20:44:15Z |
| publishDate | 2013-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-3828efbb2f7347e1a94f2680329ff8c82022-12-21T18:50:51ZengKarger PublishersCase Reports in Oncology1662-65752013-05-016226927410.1159/000345572345572Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the ElderlyT. MizunoM. IshigakiK. NakajimaT. MatsueM. FukushimaH. MinatoN. NojimaSaito AtsushiK. IshigamiH. AtsumiT. ItoM. IguchiD. UsudaH. OkamuraS. UrashimaM. AsanoA. FukudaY. IzumiN. TakekoshiT. KandaA 94-year-old female patient presented with anorexia and left axillar lymphadenopathy on admission. Her past history was angina pectoris at 83 years of age and total gastrectomy due to gastric cancer at 87 years. The family history revealed that her son had had a malignant lymphoma, the histopathological diagnosis of which was diffuse large B-cell lymphoma. A physical examination showed both cervical, axillar, and inguinal lymphadenopathy without tenderness. She had elevated lactate dehydrogenase, ferritin, and soluble interleukin-2 receptor (sIL-2R). Whole-body computed tomography confirmed the cervical, axillary, and inguinal lymphadenopathy. Gallium-68 imaging revealed positive accumulation in these superficial lymph nodes. A right inguinal lymph node biopsy showed features of Epstein-Barr virus-associated lymphoproliferative disorder. Immunohistological studies on this lymph node biopsy showed CD20-positive large cells, CD3-positive small cells, and CD30-partly-positive large cells. In situ hybridization showed Epstein-Barr virus-positive, LMP-partly-positive, and EBNA2-negative cells. She refused chemotherapy as her son had died from hematemesis during chemotherapy. She received intravenous hyperalimentation for 1 month after admission. No palpable lymph nodes were identified by physical examination or computed tomography 3 months after admission, and regression of lactate dehydrogenase, ferritin, and sIL-2R was observed. She recovered from anorexia and was discharged. She died from pneumonia 10 months later after initial symptoms of anorexia. The autopsy showed no superficial lymphadenopathy.http://www.karger.com/Article/FullText/345572ElderlyEpstein-Barr virusRemissionsIL-2R |
| spellingShingle | T. Mizuno M. Ishigaki K. Nakajima T. Matsue M. Fukushima H. Minato N. Nojima Saito Atsushi K. Ishigami H. Atsumi T. Ito M. Iguchi D. Usuda H. Okamura S. Urashima M. Asano A. Fukuda Y. Izumi N. Takekoshi T. Kanda Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly Case Reports in Oncology Elderly Epstein-Barr virus Remission sIL-2R |
| title | Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly |
| title_full | Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly |
| title_fullStr | Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly |
| title_full_unstemmed | Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly |
| title_short | Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly |
| title_sort | spontaneous remission of epstein barr virus positive diffuse large b cell lymphoma of the elderly |
| topic | Elderly Epstein-Barr virus Remission sIL-2R |
| url | http://www.karger.com/Article/FullText/345572 |
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