Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls
Aims: The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. Methods: This was a hospital-based...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2016-03-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201601-0012_Gastrointestinal_comorbidities_in_patients_with_psoriasis_in_the_Czech_Republic_The_results_of_189_patients_wi.php |
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| author | Katerina Juzlova Jana Votrubova Martina Dzambova Dana Gopfertova Jana Hercogova Zdeněk Smerhovsky |
| author_facet | Katerina Juzlova Jana Votrubova Martina Dzambova Dana Gopfertova Jana Hercogova Zdeněk Smerhovsky |
| author_sort | Katerina Juzlova |
| collection | DOAJ |
| description | Aims: The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis.
Methods: This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases.
Results: There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis.
Conclusion: Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life. |
| first_indexed | 2024-12-20T01:16:47Z |
| format | Article |
| id | doaj.art-38293c95366f467bb5b32f03635f1432 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-20T01:16:47Z |
| publishDate | 2016-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-38293c95366f467bb5b32f03635f14322022-12-21T19:58:33ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212016-03-01160110010510.5507/bp.2015.048bio-201601-0012Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controlsKaterina Juzlova0Jana Votrubova1Martina Dzambova2Dana Gopfertova3Jana Hercogova4Zdeněk Smerhovsky5Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicDepartment of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicDepartment of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicDepartment of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicDepartment of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicDepartment of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech RepublicAims: The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. Methods: This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases. Results: There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis. Conclusion: Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.https://biomed.papers.upol.cz/artkey/bio-201601-0012_Gastrointestinal_comorbidities_in_patients_with_psoriasis_in_the_Czech_Republic_The_results_of_189_patients_wi.phppsoriasiscoeliac diseaseinflammatory bowel diseases |
| spellingShingle | Katerina Juzlova Jana Votrubova Martina Dzambova Dana Gopfertova Jana Hercogova Zdeněk Smerhovsky Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls Biomedical Papers psoriasis coeliac disease inflammatory bowel diseases |
| title | Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls |
| title_full | Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls |
| title_fullStr | Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls |
| title_full_unstemmed | Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls |
| title_short | Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls |
| title_sort | gastrointestinal comorbidities in patients with psoriasis in the czech republic the results of 189 patients with psoriasis and 378 controls |
| topic | psoriasis coeliac disease inflammatory bowel diseases |
| url | https://biomed.papers.upol.cz/artkey/bio-201601-0012_Gastrointestinal_comorbidities_in_patients_with_psoriasis_in_the_Czech_Republic_The_results_of_189_patients_wi.php |
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