Abnormal brain default-mode network functional connectivity in drug addicts.
The default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3027699?pdf=render |
| _version_ | 1828385683299893248 |
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| author | Ning Ma Ying Liu Xian-Ming Fu Nan Li Chang-Xin Wang Hao Zhang Ruo-Bing Qian Hu-Sheng Xu Xiaoping Hu Da-Ren Zhang |
| author_facet | Ning Ma Ying Liu Xian-Ming Fu Nan Li Chang-Xin Wang Hao Zhang Ruo-Bing Qian Hu-Sheng Xu Xiaoping Hu Da-Ren Zhang |
| author_sort | Ning Ma |
| collection | DOAJ |
| description | The default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of the DMN, the present study examined addiction-related alteration of functional connectivity of the DMN.Resting-state functional magnetic resonance imaging data of chronic heroin users (14 males, age: 30.1±5.3 years, range from 22 to 39 years) and non-addicted controls (13 males, age: 29.8±7.2 years, range from 20 to 39 years) were investigated with independent component analysis to address their functional connectivity of the DMN.Compared with controls, heroin users showed increased functional connectivity in right hippocampus and decreased functional connectivity in right dorsal anterior cingulate cortex and left caudate in the DMN.These findings suggest drug addicts' abnormal functional organization of the DMN, and are discussed as addiction-related abnormally increased memory processing but diminished cognitive control related to attention and self-monitoring, which may underlie the hypersensitivity toward drug related cues but weakened strength of cognitive control in the state of addiction. |
| first_indexed | 2024-12-10T05:24:08Z |
| format | Article |
| id | doaj.art-3829cbaab0d24d86ae27e7f20f451752 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T05:24:08Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3829cbaab0d24d86ae27e7f20f4517522022-12-22T02:00:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1656010.1371/journal.pone.0016560Abnormal brain default-mode network functional connectivity in drug addicts.Ning MaYing LiuXian-Ming FuNan LiChang-Xin WangHao ZhangRuo-Bing QianHu-Sheng XuXiaoping HuDa-Ren ZhangThe default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of the DMN, the present study examined addiction-related alteration of functional connectivity of the DMN.Resting-state functional magnetic resonance imaging data of chronic heroin users (14 males, age: 30.1±5.3 years, range from 22 to 39 years) and non-addicted controls (13 males, age: 29.8±7.2 years, range from 20 to 39 years) were investigated with independent component analysis to address their functional connectivity of the DMN.Compared with controls, heroin users showed increased functional connectivity in right hippocampus and decreased functional connectivity in right dorsal anterior cingulate cortex and left caudate in the DMN.These findings suggest drug addicts' abnormal functional organization of the DMN, and are discussed as addiction-related abnormally increased memory processing but diminished cognitive control related to attention and self-monitoring, which may underlie the hypersensitivity toward drug related cues but weakened strength of cognitive control in the state of addiction.http://europepmc.org/articles/PMC3027699?pdf=render |
| spellingShingle | Ning Ma Ying Liu Xian-Ming Fu Nan Li Chang-Xin Wang Hao Zhang Ruo-Bing Qian Hu-Sheng Xu Xiaoping Hu Da-Ren Zhang Abnormal brain default-mode network functional connectivity in drug addicts. PLoS ONE |
| title | Abnormal brain default-mode network functional connectivity in drug addicts. |
| title_full | Abnormal brain default-mode network functional connectivity in drug addicts. |
| title_fullStr | Abnormal brain default-mode network functional connectivity in drug addicts. |
| title_full_unstemmed | Abnormal brain default-mode network functional connectivity in drug addicts. |
| title_short | Abnormal brain default-mode network functional connectivity in drug addicts. |
| title_sort | abnormal brain default mode network functional connectivity in drug addicts |
| url | http://europepmc.org/articles/PMC3027699?pdf=render |
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