Emx1 Is Required for Neocortical Area Patterning.
Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcription factor Emx1 does not contr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4762677?pdf=render |
| _version_ | 1819128692052328448 |
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| author | Adam M Stocker Dennis D M O'Leary |
| author_facet | Adam M Stocker Dennis D M O'Leary |
| author_sort | Adam M Stocker |
| collection | DOAJ |
| description | Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcription factor Emx1 does not contribute to neocortical area patterning, those studies were performed at perinatal ages prior to the emergence of primary areas. We therefore examined two different Emx1 deletion mouse lines once primary areas possess mature features. Following the deletion of Emx1, the frontal and motor areas were expanded while the primary visual area was reduced, and overall the areas shifted posterio-medially. This patterning phenotype was consistent between the two Emx1 deletion strategies. The present study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area. |
| first_indexed | 2024-12-22T08:31:51Z |
| format | Article |
| id | doaj.art-382c385683b44038af05560079c695eb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T08:31:51Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-382c385683b44038af05560079c695eb2022-12-21T18:32:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014990010.1371/journal.pone.0149900Emx1 Is Required for Neocortical Area Patterning.Adam M StockerDennis D M O'LearyEstablishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcription factor Emx1 does not contribute to neocortical area patterning, those studies were performed at perinatal ages prior to the emergence of primary areas. We therefore examined two different Emx1 deletion mouse lines once primary areas possess mature features. Following the deletion of Emx1, the frontal and motor areas were expanded while the primary visual area was reduced, and overall the areas shifted posterio-medially. This patterning phenotype was consistent between the two Emx1 deletion strategies. The present study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area.http://europepmc.org/articles/PMC4762677?pdf=render |
| spellingShingle | Adam M Stocker Dennis D M O'Leary Emx1 Is Required for Neocortical Area Patterning. PLoS ONE |
| title | Emx1 Is Required for Neocortical Area Patterning. |
| title_full | Emx1 Is Required for Neocortical Area Patterning. |
| title_fullStr | Emx1 Is Required for Neocortical Area Patterning. |
| title_full_unstemmed | Emx1 Is Required for Neocortical Area Patterning. |
| title_short | Emx1 Is Required for Neocortical Area Patterning. |
| title_sort | emx1 is required for neocortical area patterning |
| url | http://europepmc.org/articles/PMC4762677?pdf=render |
| work_keys_str_mv | AT adammstocker emx1isrequiredforneocorticalareapatterning AT dennisdmoleary emx1isrequiredforneocorticalareapatterning |