4,8-Dicarboxyl-8,9-iridoid-1-glycoside inhibits apoptosis in human osteoarthritis chondrocytes via enhanced c-MYC-mediated cholesterol metabolism in vitro

4,8-Dicarboxyl-8,9-iridoid-1-glycoside inhibits apoptosis in human osteoarthritis chondrocytes via enhanced c-MYC-mediated cholesterol metabolism in vitro

Abstract Background Osteoarthritis (OA) is a degenerative disease related to cholesterol metabolism disorders. However, current therapies for OA are insufficient and no convincing disease-modifying OA drugs exist. Therefore, we aimed to elucidate the mechanism by which borojoa iridoid glycoside (BIG...

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Bibliographic Details
Main Authors: WeiBing Wang, HaiMin Mai, Huang Xu, BaoSheng Jing, CuiYu Yu, XiaoTing Li, DanGui Chen, Yuan Huang, MeiMang Shao, Tao Pan
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Borojoa
Cholesterol metabolism
Apoptosis
Autophagy
Online Access:https://doi.org/10.1186/s13075-023-03217-1

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