Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature
Abstract Introduction Isolated primary sacral diffuse large B cell non-Hodgkin’s lymphoma is a very rare entity, and only 11 cases have been reported previously. Case presentation A 36-year-old man was referred with low backache and radiculopathy pain with a clinico-radiological and cytological diag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-021-02153-1 |
| _version_ | 1818336831573327872 |
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| author | Satya Vijay Chigurupati Mridula Shukla Manoj Pandey |
| author_facet | Satya Vijay Chigurupati Mridula Shukla Manoj Pandey |
| author_sort | Satya Vijay Chigurupati |
| collection | DOAJ |
| description | Abstract Introduction Isolated primary sacral diffuse large B cell non-Hodgkin’s lymphoma is a very rare entity, and only 11 cases have been reported previously. Case presentation A 36-year-old man was referred with low backache and radiculopathy pain with a clinico-radiological and cytological diagnosis of sacral metastasis. Histopathological examination and immunohistochemistry of image-guided tissue core biopsy from the sacral mass confirmed it as high-grade diffuse large B cell lymphoma (DLBCL). With normal blood counts and bone marrow, and no lesions elsewhere on imaging, he was staged IAE and received 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen chemotherapy followed by radiotherapy. The patient has completed a 3-year follow-up and is doing well with yearly imaging showing no evidence of active disease or recurrence. Conclusions The case shows the importance of an image-guided core biopsy and immunohistochemistry over a fine needle aspiration cytology in select cases as it can alter the treatment and outcome in patients. Because of rarity, the treatment and prognosis in primary sacral NHL is not still very clear as it is treated as per the guidelines of treatment of bone lymphoma. |
| first_indexed | 2024-12-13T14:45:34Z |
| format | Article |
| id | doaj.art-382e13e2e6044301b067f8ddb88058da |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-13T14:45:34Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-382e13e2e6044301b067f8ddb88058da2022-12-21T23:41:28ZengBMCWorld Journal of Surgical Oncology1477-78192021-02-011911810.1186/s12957-021-02153-1Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literatureSatya Vijay Chigurupati0Mridula Shukla1Manoj Pandey2Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu UniversityDr. Lal Path LabDepartment of Surgical Oncology, Institute of Medical Science, Banaras Hindu UniversityAbstract Introduction Isolated primary sacral diffuse large B cell non-Hodgkin’s lymphoma is a very rare entity, and only 11 cases have been reported previously. Case presentation A 36-year-old man was referred with low backache and radiculopathy pain with a clinico-radiological and cytological diagnosis of sacral metastasis. Histopathological examination and immunohistochemistry of image-guided tissue core biopsy from the sacral mass confirmed it as high-grade diffuse large B cell lymphoma (DLBCL). With normal blood counts and bone marrow, and no lesions elsewhere on imaging, he was staged IAE and received 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen chemotherapy followed by radiotherapy. The patient has completed a 3-year follow-up and is doing well with yearly imaging showing no evidence of active disease or recurrence. Conclusions The case shows the importance of an image-guided core biopsy and immunohistochemistry over a fine needle aspiration cytology in select cases as it can alter the treatment and outcome in patients. Because of rarity, the treatment and prognosis in primary sacral NHL is not still very clear as it is treated as per the guidelines of treatment of bone lymphoma.https://doi.org/10.1186/s12957-021-02153-1Primary bone lymphomaNon-Hodgkin's lymphomaSacrumDiffuse large B cell lymphoma |
| spellingShingle | Satya Vijay Chigurupati Mridula Shukla Manoj Pandey Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature World Journal of Surgical Oncology Primary bone lymphoma Non-Hodgkin's lymphoma Sacrum Diffuse large B cell lymphoma |
| title | Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature |
| title_full | Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature |
| title_fullStr | Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature |
| title_full_unstemmed | Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature |
| title_short | Primary sacral non-Hodgkin’s lymphoma: report of a case and systematic review of literature |
| title_sort | primary sacral non hodgkin s lymphoma report of a case and systematic review of literature |
| topic | Primary bone lymphoma Non-Hodgkin's lymphoma Sacrum Diffuse large B cell lymphoma |
| url | https://doi.org/10.1186/s12957-021-02153-1 |
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