Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery
Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/4/527 |
| _version_ | 1797539739082948608 |
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| author | Jinkyung Park Dahee Jeong Meeryoung Song Bonglee Kim |
| author_facet | Jinkyung Park Dahee Jeong Meeryoung Song Bonglee Kim |
| author_sort | Jinkyung Park |
| collection | DOAJ |
| description | Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs. |
| first_indexed | 2024-03-10T12:50:07Z |
| format | Article |
| id | doaj.art-382eb5ae21b94ac1b638fddfee94db2a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T12:50:07Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-382eb5ae21b94ac1b638fddfee94db2a2023-11-21T13:05:59ZengMDPI AGAntioxidants2076-39212021-03-0110452710.3390/antiox10040527Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug DiscoveryJinkyung Park0Dahee Jeong1Meeryoung Song2Bonglee Kim3College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaMetastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.https://www.mdpi.com/2076-3921/10/4/527herbal medicinecancer metastasislung cancercolorectal cancergastric cancerliver cancer |
| spellingShingle | Jinkyung Park Dahee Jeong Meeryoung Song Bonglee Kim Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery Antioxidants herbal medicine cancer metastasis lung cancer colorectal cancer gastric cancer liver cancer |
| title | Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery |
| title_full | Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery |
| title_fullStr | Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery |
| title_full_unstemmed | Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery |
| title_short | Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery |
| title_sort | recent advances in anti metastatic approaches of herbal medicines in 5 major cancers from traditional medicine to modern drug discovery |
| topic | herbal medicine cancer metastasis lung cancer colorectal cancer gastric cancer liver cancer |
| url | https://www.mdpi.com/2076-3921/10/4/527 |
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