Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure
The employment of molecular tools with nucleic acid binding ability to specifically control crucial cellular functions represents an important scientific area at the border between biochemistry and pharmaceutical chemistry. In this review we describe several molecular systems of natural or artificia...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-06-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.6.138 |
| _version_ | 1811277553159110656 |
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| author | Giovanni N. Roviello Domenica Musumeci Valentina Roviello Marina Pirtskhalava Alexander Egoyan Merab Mirtskhulava |
| author_facet | Giovanni N. Roviello Domenica Musumeci Valentina Roviello Marina Pirtskhalava Alexander Egoyan Merab Mirtskhulava |
| author_sort | Giovanni N. Roviello |
| collection | DOAJ |
| description | The employment of molecular tools with nucleic acid binding ability to specifically control crucial cellular functions represents an important scientific area at the border between biochemistry and pharmaceutical chemistry. In this review we describe several molecular systems of natural or artificial origin, which are able to bind polyriboadenylic acid (poly(rA)) both in its single-stranded or structured forms. Due to the fundamental role played by the poly(rA) tail in the maturation and stability of mRNA, as well as in the initiation of the translation process, compounds able to bind this RNA tract, influencing the mRNA fate, are of special interest for developing innovative biomedical strategies mainly in the field of anticancer therapy. |
| first_indexed | 2024-04-13T00:18:50Z |
| format | Article |
| id | doaj.art-3830c91dc1b646fcaeb308fb46b309fc |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-04-13T00:18:50Z |
| publishDate | 2015-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-3830c91dc1b646fcaeb308fb46b309fc2022-12-22T03:10:50ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862015-06-01611338134710.3762/bjnano.6.1382190-4286-6-138Natural and artificial binders of polyriboadenylic acid and their effect on RNA structureGiovanni N. Roviello0Domenica Musumeci1Valentina Roviello2Marina Pirtskhalava3Alexander Egoyan4Merab Mirtskhulava5Istituto di Biostrutture e Bioimmagini - CNR, via Mezzocannone 16, 80134 Napoli, ItalyIstituto di Biostrutture e Bioimmagini - CNR, via Mezzocannone 16, 80134 Napoli, ItalyDipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale (DICMaPI), Università di Napoli “Federico II”, 80125 Napoli, ItalyGeomedi University, 3 Krtsanisi Street, 0114 Tbilisi, GeorgiaGeomedi University, 3 Krtsanisi Street, 0114 Tbilisi, GeorgiaGeomedi University, 3 Krtsanisi Street, 0114 Tbilisi, GeorgiaThe employment of molecular tools with nucleic acid binding ability to specifically control crucial cellular functions represents an important scientific area at the border between biochemistry and pharmaceutical chemistry. In this review we describe several molecular systems of natural or artificial origin, which are able to bind polyriboadenylic acid (poly(rA)) both in its single-stranded or structured forms. Due to the fundamental role played by the poly(rA) tail in the maturation and stability of mRNA, as well as in the initiation of the translation process, compounds able to bind this RNA tract, influencing the mRNA fate, are of special interest for developing innovative biomedical strategies mainly in the field of anticancer therapy.https://doi.org/10.3762/bjnano.6.138nucleopeptidespoly(rA) bindersRNAself-structures |
| spellingShingle | Giovanni N. Roviello Domenica Musumeci Valentina Roviello Marina Pirtskhalava Alexander Egoyan Merab Mirtskhulava Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure Beilstein Journal of Nanotechnology nucleopeptides poly(rA) binders RNA self-structures |
| title | Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure |
| title_full | Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure |
| title_fullStr | Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure |
| title_full_unstemmed | Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure |
| title_short | Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure |
| title_sort | natural and artificial binders of polyriboadenylic acid and their effect on rna structure |
| topic | nucleopeptides poly(rA) binders RNA self-structures |
| url | https://doi.org/10.3762/bjnano.6.138 |
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