Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants

Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants

The SHANK scaffolding proteins are important organizers for signaling proteins in the postsynapse of excitatory neurons. The functional significance of SHANK proteins becomes apparent by the wide spectrum of neurodevelopmental and neuropsychiatric disorders associated with SHANK variants in human pa...

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Bibliographic Details
Main Authors: Ahmed Eltokhi, Gudrun Rappold, Rolf Sprengel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SHANK2 domains
SHANK2 isoforms
SHANK2 gene variants
autism spectrum disorder
intellectual disability
schizophrenia
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00240/full

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