Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition o...
| Váldodahkkit: | , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Elsevier
2002-07-01
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| Ráidu: | Journal of Lipid Research |
| Fáttát: | |
| Liŋkkat: | http://www.sciencedirect.com/science/article/pii/S0022227520314759 |
| _version_ | 1829138305096089600 |
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| author | B. Kalderon V. Sheena S. Shachrur R. Hertz J. Bar-Tana |
| author_facet | B. Kalderon V. Sheena S. Shachrur R. Hertz J. Bar-Tana |
| author_sort | B. Kalderon |
| collection | DOAJ |
| description | The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs. |
| first_indexed | 2024-12-14T19:14:35Z |
| format | Article |
| id | doaj.art-38327af260f4494a97c72a56cee9c5a2 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T19:14:35Z |
| publishDate | 2002-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-38327af260f4494a97c72a56cee9c5a22022-12-21T22:50:38ZengElsevierJournal of Lipid Research0022-22752002-07-0143711251132Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometryB. Kalderon0V. Sheena1S. Shachrur2R. Hertz3J. Bar-Tana4Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120To whom correspondence should be addressed; Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.http://www.sciencedirect.com/science/article/pii/S0022227520314759fatty acidshypolipidemic drugselectrospray ionization tandem mass spectrometryhepatocyte nuclear factor-4α |
| spellingShingle | B. Kalderon V. Sheena S. Shachrur R. Hertz J. Bar-Tana Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry Journal of Lipid Research fatty acids hypolipidemic drugs electrospray ionization tandem mass spectrometry hepatocyte nuclear factor-4α |
| title | Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry |
| title_full | Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry |
| title_fullStr | Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry |
| title_full_unstemmed | Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry |
| title_short | Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry |
| title_sort | modulation by nutrients and drugs of liver acyl coas analyzed by mass spectrometry |
| topic | fatty acids hypolipidemic drugs electrospray ionization tandem mass spectrometry hepatocyte nuclear factor-4α |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520314759 |
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