Distinct SoxB1 networks are required for naïve and primed pluripotency

Distinct SoxB1 networks are required for naïve and primed pluripotency

Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown. Here, we show that Sox2...

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Bibliographic Details
Main Authors: Andrea Corsinotti, Frederick CK Wong, Tülin Tatar, Iwona Szczerbinska, Florian Halbritter, Douglas Colby, Sabine Gogolok, Raphaël Pantier, Kirsten Liggat, Elham S Mirfazeli, Elisa Hall-Ponsele, Nicholas P Mullin, Valerie Wilson, Ian Chambers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
Pluripotency
Sox
transcription factors
Embryonic stem cells
Epiblast stem cells
Online Access:https://elifesciences.org/articles/27746

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