Biological Functions of Nitric Oxide in the Brain and Brain Stem
Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and me...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2022-06-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_92098.html |
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| author | Zahra Rezae Sohrab Hajizadeh Zahra Piri |
| author_facet | Zahra Rezae Sohrab Hajizadeh Zahra Piri |
| author_sort | Zahra Rezae |
| collection | DOAJ |
| description | Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain.
Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain.
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| first_indexed | 2024-04-10T19:31:09Z |
| format | Article |
| id | doaj.art-3833ccc7b6e24297a79387b54a122731 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-04-10T19:31:09Z |
| publishDate | 2022-06-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-3833ccc7b6e24297a79387b54a1227312023-01-30T09:43:25ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432022-06-0129656857610.34172/JKMU.2022.71Biological Functions of Nitric Oxide in the Brain and Brain StemZahra Rezae0 Sohrab Hajizadeh1Zahra Piri 2Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IranDepartment of Physiology, Medical School, Tarbiat Modares University, Tehran, IranDepartment of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IranNitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain. Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain. https://jkmu.kmu.ac.ir/article_92098.htmlnervous system nitric oxide brain brain stem |
| spellingShingle | Zahra Rezae Sohrab Hajizadeh Zahra Piri Biological Functions of Nitric Oxide in the Brain and Brain Stem Journal of Kerman University of Medical Sciences nervous system nitric oxide brain brain stem |
| title | Biological Functions of Nitric Oxide in the Brain and Brain Stem |
| title_full | Biological Functions of Nitric Oxide in the Brain and Brain Stem |
| title_fullStr | Biological Functions of Nitric Oxide in the Brain and Brain Stem |
| title_full_unstemmed | Biological Functions of Nitric Oxide in the Brain and Brain Stem |
| title_short | Biological Functions of Nitric Oxide in the Brain and Brain Stem |
| title_sort | biological functions of nitric oxide in the brain and brain stem |
| topic | nervous system nitric oxide brain brain stem |
| url | https://jkmu.kmu.ac.ir/article_92098.html |
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