Adenosine A2A receptors control generalization of contextual fear in rats

Abstract Fear learning is essential to survival, but traumatic events may lead to abnormal fear consolidation and overgeneralization, triggering fear responses in safe environments, as occurs in post-traumatic stress disorder (PTSD). Adenosine A2A receptors (A2AR) control emotional memory and fear c...

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Bibliographic Details
Main Authors: Ana P. Simões, Marina A. M. Portes, Cátia R. Lopes, Felipe Vanz, Vanessa S. Lourenço, Anna Pliássova, Ingride L. Gaspar, Henrique B. Silva, Ângelo R. Tomé, Paula M. Canas, Rui D. Prediger, Rodrigo A. Cunha
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02613-0