Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar
Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between se...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/1/127 |
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| author | Hanaa Mousa Nazmul Islam Vijay Ganji Susu M. Zughaier |
| author_facet | Hanaa Mousa Nazmul Islam Vijay Ganji Susu M. Zughaier |
| author_sort | Hanaa Mousa |
| collection | DOAJ |
| description | Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12–20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris. |
| first_indexed | 2024-03-10T13:35:37Z |
| format | Article |
| id | doaj.art-3834a4850b9640749eb6bed48f4dd05f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:35:37Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3834a4850b9640749eb6bed48f4dd05f2023-11-21T07:30:11ZengMDPI AGNutrients2072-66432020-12-0113112710.3390/nu13010127Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in QatarHanaa Mousa0Nazmul Islam1Vijay Ganji2Susu M. Zughaier3College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, QatarPublic Health Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, QatarHuman Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, QatarLow serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12–20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.https://www.mdpi.com/2072-6643/13/1/127vitamin D25-hydroxyvitamin DHDLmonocyte percentageMHRinflammation |
| spellingShingle | Hanaa Mousa Nazmul Islam Vijay Ganji Susu M. Zughaier Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar Nutrients vitamin D 25-hydroxyvitamin D HDL monocyte percentage MHR inflammation |
| title | Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
| title_full | Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
| title_fullStr | Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
| title_full_unstemmed | Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
| title_short | Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
| title_sort | serum 25 hydroxyvitamin d is inversely associated with monocyte percentage to hdl cholesterol ratio among young healthy adults in qatar |
| topic | vitamin D 25-hydroxyvitamin D HDL monocyte percentage MHR inflammation |
| url | https://www.mdpi.com/2072-6643/13/1/127 |
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