Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder
Background: We investigated the association between serum 25(OH) D levels and depressive symptoms in patients with major depressive disorder (MDD). Methods: Eighty-five adults, 44 drug free patients with MDD and 41 apparently healthy controls, participated in the study. The Hamilton Depression Rati...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-05-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/3542 |
| _version_ | 1818876819760218112 |
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| author | Leila Dana-Alamdari Sorayya Kheirouri Seyed Gholamreza Noorazar |
| author_facet | Leila Dana-Alamdari Sorayya Kheirouri Seyed Gholamreza Noorazar |
| author_sort | Leila Dana-Alamdari |
| collection | DOAJ |
| description | Background: We investigated the association between serum 25(OH) D levels and depressive symptoms in patients with major depressive disorder (MDD).
Methods: Eighty-five adults, 44 drug free patients with MDD and 41 apparently healthy controls, participated in the study. The Hamilton Depression Rating Scale was used to assess severity of major depression. Mental health of the controls was assessed according to DSM-IV criteria. Stress level of the participants was assessed by the Holmes and Rahe stress scale. Serum 25(OH) D levels was measured by immunochemiluminescence assay. Vitamin D deficiency was defined as a serum 25(OH) D concentration of lower than 20 ng/ml.
Results: Depressed patients had the higher levels of stress. There was a positive correlation between stress level and disease severity (r= 0.32, P= 0.03). In total participants, mean percentage of vitamin D deficiency was 77.6% with 75% in patients and 80.5% in the healthy subjects. There were no differences between the two groups in serum 25(OH) D levels and percentage of subjects with the vitamin deficiency. A negative correlation was observed between disease severity and serum 25(OH) D level of patients with depression episodes < 2 y (r= -0.38, P = 0.08) and winter samples (samples collected and measured from December to march, r= -0.62, P = 0.004).
Conclusion: Serum 25(OH) D levels were not associated with depression. However, the inverse relationship between levels of vitamin D and depressive symptoms in current depression episodes and in sun-deprived season warrants further investigation. |
| first_indexed | 2024-12-19T13:48:27Z |
| format | Article |
| id | doaj.art-383a500aa4004c249ef6856f830044f1 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-19T13:48:27Z |
| publishDate | 2015-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-383a500aa4004c249ef6856f830044f12022-12-21T20:18:49ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932015-05-014453407Serum 25-Hydroxyvitamin D in Patients with Major Depressive DisorderLeila Dana-Alamdari0Sorayya Kheirouri1Seyed Gholamreza Noorazar2Dept. of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Dept. of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.Background: We investigated the association between serum 25(OH) D levels and depressive symptoms in patients with major depressive disorder (MDD). Methods: Eighty-five adults, 44 drug free patients with MDD and 41 apparently healthy controls, participated in the study. The Hamilton Depression Rating Scale was used to assess severity of major depression. Mental health of the controls was assessed according to DSM-IV criteria. Stress level of the participants was assessed by the Holmes and Rahe stress scale. Serum 25(OH) D levels was measured by immunochemiluminescence assay. Vitamin D deficiency was defined as a serum 25(OH) D concentration of lower than 20 ng/ml. Results: Depressed patients had the higher levels of stress. There was a positive correlation between stress level and disease severity (r= 0.32, P= 0.03). In total participants, mean percentage of vitamin D deficiency was 77.6% with 75% in patients and 80.5% in the healthy subjects. There were no differences between the two groups in serum 25(OH) D levels and percentage of subjects with the vitamin deficiency. A negative correlation was observed between disease severity and serum 25(OH) D level of patients with depression episodes < 2 y (r= -0.38, P = 0.08) and winter samples (samples collected and measured from December to march, r= -0.62, P = 0.004). Conclusion: Serum 25(OH) D levels were not associated with depression. However, the inverse relationship between levels of vitamin D and depressive symptoms in current depression episodes and in sun-deprived season warrants further investigation.https://ijph.tums.ac.ir/index.php/ijph/article/view/3542Current depressionDepressionDepression severityVitamin D |
| spellingShingle | Leila Dana-Alamdari Sorayya Kheirouri Seyed Gholamreza Noorazar Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder Iranian Journal of Public Health Current depression Depression Depression severity Vitamin D |
| title | Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder |
| title_full | Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder |
| title_fullStr | Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder |
| title_full_unstemmed | Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder |
| title_short | Serum 25-Hydroxyvitamin D in Patients with Major Depressive Disorder |
| title_sort | serum 25 hydroxyvitamin d in patients with major depressive disorder |
| topic | Current depression Depression Depression severity Vitamin D |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/3542 |
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