Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
Abstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty aci...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02269-0 |
| _version_ | 1818743790418001920 |
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| author | Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak |
| author_facet | Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak |
| author_sort | Amritpal S. Bhullar |
| collection | DOAJ |
| description | Abstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer. |
| first_indexed | 2024-12-18T02:34:01Z |
| format | Article |
| id | doaj.art-383b0da5f06f447e92053de802692a2e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T02:34:01Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-383b0da5f06f447e92053de802692a2e2022-12-21T21:23:50ZengNature PortfolioScientific Reports2045-23222021-11-011111810.1038/s41598-021-02269-0Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary reportAmritpal S. Bhullar0Irma Magaly Rivas-Serna1Ana Anoveros-Barrera2Abha Dunichand-Hoedl3David Bigam4Rachel G. Khadaroo5Todd McMullen6Oliver Bathe7Charles T. Putman8Vickie Baracos9Michael T. Clandinin10Vera C. Mazurak11Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationDepartment of Surgery, University of AlbertaDepartment of Surgery, University of AlbertaDepartment of Surgery, University of AlbertaDepartments of Surgery and Oncology, Tom Baker Cancer Centre, University of CalgaryFaculty of Kinesiology, Sport, and Recreation, University of AlbertaDepartment of Oncology, University of AlbertaDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationDepartment of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research InnovationAbstract Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer.https://doi.org/10.1038/s41598-021-02269-0 |
| spellingShingle | Amritpal S. Bhullar Irma Magaly Rivas-Serna Ana Anoveros-Barrera Abha Dunichand-Hoedl David Bigam Rachel G. Khadaroo Todd McMullen Oliver Bathe Charles T. Putman Vickie Baracos Michael T. Clandinin Vera C. Mazurak Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report Scientific Reports |
| title | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
| title_full | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
| title_fullStr | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
| title_full_unstemmed | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
| title_short | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
| title_sort | depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery preliminary report |
| url | https://doi.org/10.1038/s41598-021-02269-0 |
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