Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of chloroquine (CQ) activates AT...

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Bibliographic Details
Main Authors: Minxian Qian, Zuojun Liu, Linyuan Peng, Xiaolong Tang, Fanbiao Meng, Ying Ao, Mingyan Zhou, Ming Wang, Xinyue Cao, Baoming Qin, Zimei Wang, Zhongjun Zhou, Guangming Wang, Zhengliang Gao, Jun Xu, Baohua Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
ATM
SIRT6
genome stability
ageing
Online Access:https://elifesciences.org/articles/34836

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