Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease
Alzheimer’s disease (AD) is a prevalent neurodegenerative disease that has become one of the main factors affecting human health. It has serious impacts on individuals, families, and society. With the development of population aging, the incidence of AD will further increase worldwide. Emerging evid...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1348844/full |
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| author | Honghu Song Honghu Song Jiancheng Liu Linjie Wang Xiaomin Hu Jiayu Li Jiayu Li Li Zhu Li Zhu Rizhao Pang Anren Zhang |
| author_facet | Honghu Song Honghu Song Jiancheng Liu Linjie Wang Xiaomin Hu Jiayu Li Jiayu Li Li Zhu Li Zhu Rizhao Pang Anren Zhang |
| author_sort | Honghu Song |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a prevalent neurodegenerative disease that has become one of the main factors affecting human health. It has serious impacts on individuals, families, and society. With the development of population aging, the incidence of AD will further increase worldwide. Emerging evidence suggests that many physiological metabolic processes, such as lipid metabolism, are implicated in the pathogenesis of AD. Bile acids, as the main undertakers of lipid metabolism, play an important role in the occurrence and development of Alzheimer’s disease. Tauroursodeoxycholic acid, an endogenous bile acid, has been proven to possess therapeutic effects in different neurodegenerative diseases, including Alzheimer’s disease. This review tries to find the relationship between bile acid metabolism and AD, as well as explore the therapeutic potential of bile acid taurocursodeoxycholic acid for this disease. The potential mechanisms of taurocursodeoxycholic acid may include reducing the deposition of Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation and aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, and improving metabolic disorders. The objective of this study is to shed light on the use of tauroursodeoxycholic acid preparations in the prevention and treatment of AD, with the aim of identifying effective treatment targets and clarifying various treatment mechanisms involved in this disease. |
| first_indexed | 2024-03-07T23:51:50Z |
| format | Article |
| id | doaj.art-383c806453884d8a86f48895c0b803d5 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-07T23:51:50Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-383c806453884d8a86f48895c0b803d52024-02-19T04:28:36ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-02-011810.3389/fnins.2024.13488441348844Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s diseaseHonghu Song0Honghu Song1Jiancheng Liu2Linjie Wang3Xiaomin Hu4Jiayu Li5Jiayu Li6Li Zhu7Li Zhu8Rizhao Pang9Anren Zhang10School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, ChinaAlzheimer’s disease (AD) is a prevalent neurodegenerative disease that has become one of the main factors affecting human health. It has serious impacts on individuals, families, and society. With the development of population aging, the incidence of AD will further increase worldwide. Emerging evidence suggests that many physiological metabolic processes, such as lipid metabolism, are implicated in the pathogenesis of AD. Bile acids, as the main undertakers of lipid metabolism, play an important role in the occurrence and development of Alzheimer’s disease. Tauroursodeoxycholic acid, an endogenous bile acid, has been proven to possess therapeutic effects in different neurodegenerative diseases, including Alzheimer’s disease. This review tries to find the relationship between bile acid metabolism and AD, as well as explore the therapeutic potential of bile acid taurocursodeoxycholic acid for this disease. The potential mechanisms of taurocursodeoxycholic acid may include reducing the deposition of Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation and aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, and improving metabolic disorders. The objective of this study is to shed light on the use of tauroursodeoxycholic acid preparations in the prevention and treatment of AD, with the aim of identifying effective treatment targets and clarifying various treatment mechanisms involved in this disease.https://www.frontiersin.org/articles/10.3389/fnins.2024.1348844/fulltauroursodeoxycholic acidAlzheimer’s diseasebile acidsneurodegenerative diseasesmechanisms |
| spellingShingle | Honghu Song Honghu Song Jiancheng Liu Linjie Wang Xiaomin Hu Jiayu Li Jiayu Li Li Zhu Li Zhu Rizhao Pang Anren Zhang Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease Frontiers in Neuroscience tauroursodeoxycholic acid Alzheimer’s disease bile acids neurodegenerative diseases mechanisms |
| title | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease |
| title_full | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease |
| title_fullStr | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease |
| title_full_unstemmed | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease |
| title_short | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease |
| title_sort | tauroursodeoxycholic acid a bile acid that may be used for the prevention and treatment of alzheimer s disease |
| topic | tauroursodeoxycholic acid Alzheimer’s disease bile acids neurodegenerative diseases mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1348844/full |
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