Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
A novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were f...
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Language: | English |
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Elsevier
2015-04-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215000181 |
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author | Faming Chen Junhua Li Biancheng Sun Hong Zhang Rusheng Zhang Jie Yuan Xinhua Ou Wen Ye Jingfang Chen Yunzhi Liu Yiwei Huang |
author_facet | Faming Chen Junhua Li Biancheng Sun Hong Zhang Rusheng Zhang Jie Yuan Xinhua Ou Wen Ye Jingfang Chen Yunzhi Liu Yiwei Huang |
author_sort | Faming Chen |
collection | DOAJ |
description | A novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were found in the hemagglutinin protein (HA). Amino acid deletions were found at positions 69–73 of the neuraminidase protein (NA) and 218–230 of the non-structural protein (NS1). All viral genes except PB1 were essentially identical to the sequences of other Chinese influenza A H7N9 isolates. Overall, A/Changsha/1/2013(H7N9) is highly homologous to other H7N9 avian influenza viruses isolated in mainland China. |
first_indexed | 2024-12-12T09:19:40Z |
format | Article |
id | doaj.art-383e451428ad4517b5f11be8858fc812 |
institution | Directory Open Access Journal |
issn | 1201-9712 1878-3511 |
language | English |
last_indexed | 2024-12-12T09:19:40Z |
publishDate | 2015-04-01 |
publisher | Elsevier |
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series | International Journal of Infectious Diseases |
spelling | doaj.art-383e451428ad4517b5f11be8858fc8122022-12-22T00:29:16ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C13013110.1016/j.ijid.2015.01.013Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in ChinaFaming Chen0Junhua Li1Biancheng Sun2Hong Zhang3Rusheng Zhang4Jie Yuan5Xinhua Ou6Wen Ye7Jingfang Chen8Yunzhi Liu9Yiwei Huang10Changsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaA novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were found in the hemagglutinin protein (HA). Amino acid deletions were found at positions 69–73 of the neuraminidase protein (NA) and 218–230 of the non-structural protein (NS1). All viral genes except PB1 were essentially identical to the sequences of other Chinese influenza A H7N9 isolates. Overall, A/Changsha/1/2013(H7N9) is highly homologous to other H7N9 avian influenza viruses isolated in mainland China.http://www.sciencedirect.com/science/article/pii/S1201971215000181Avian influenza virusGenetic analysisH7N9Influenza surveillanceMutations |
spellingShingle | Faming Chen Junhua Li Biancheng Sun Hong Zhang Rusheng Zhang Jie Yuan Xinhua Ou Wen Ye Jingfang Chen Yunzhi Liu Yiwei Huang Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China International Journal of Infectious Diseases Avian influenza virus Genetic analysis H7N9 Influenza surveillance Mutations |
title | Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China |
title_full | Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China |
title_fullStr | Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China |
title_full_unstemmed | Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China |
title_short | Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China |
title_sort | isolation and characteristic analysis of a novel strain h7n9 of avian influenza virus a from a patient with influenza like symptoms in china |
topic | Avian influenza virus Genetic analysis H7N9 Influenza surveillance Mutations |
url | http://www.sciencedirect.com/science/article/pii/S1201971215000181 |
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