Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China

A novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were f...

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Main Authors: Faming Chen, Junhua Li, Biancheng Sun, Hong Zhang, Rusheng Zhang, Jie Yuan, Xinhua Ou, Wen Ye, Jingfang Chen, Yunzhi Liu, Yiwei Huang
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:International Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971215000181
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author Faming Chen
Junhua Li
Biancheng Sun
Hong Zhang
Rusheng Zhang
Jie Yuan
Xinhua Ou
Wen Ye
Jingfang Chen
Yunzhi Liu
Yiwei Huang
author_facet Faming Chen
Junhua Li
Biancheng Sun
Hong Zhang
Rusheng Zhang
Jie Yuan
Xinhua Ou
Wen Ye
Jingfang Chen
Yunzhi Liu
Yiwei Huang
author_sort Faming Chen
collection DOAJ
description A novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were found in the hemagglutinin protein (HA). Amino acid deletions were found at positions 69–73 of the neuraminidase protein (NA) and 218–230 of the non-structural protein (NS1). All viral genes except PB1 were essentially identical to the sequences of other Chinese influenza A H7N9 isolates. Overall, A/Changsha/1/2013(H7N9) is highly homologous to other H7N9 avian influenza viruses isolated in mainland China.
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spelling doaj.art-383e451428ad4517b5f11be8858fc8122022-12-22T00:29:16ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C13013110.1016/j.ijid.2015.01.013Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in ChinaFaming Chen0Junhua Li1Biancheng Sun2Hong Zhang3Rusheng Zhang4Jie Yuan5Xinhua Ou6Wen Ye7Jingfang Chen8Yunzhi Liu9Yiwei Huang10Changsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaChangsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaHunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, ChinaA novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186 V were found in the hemagglutinin protein (HA). Amino acid deletions were found at positions 69–73 of the neuraminidase protein (NA) and 218–230 of the non-structural protein (NS1). All viral genes except PB1 were essentially identical to the sequences of other Chinese influenza A H7N9 isolates. Overall, A/Changsha/1/2013(H7N9) is highly homologous to other H7N9 avian influenza viruses isolated in mainland China.http://www.sciencedirect.com/science/article/pii/S1201971215000181Avian influenza virusGenetic analysisH7N9Influenza surveillanceMutations
spellingShingle Faming Chen
Junhua Li
Biancheng Sun
Hong Zhang
Rusheng Zhang
Jie Yuan
Xinhua Ou
Wen Ye
Jingfang Chen
Yunzhi Liu
Yiwei Huang
Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
International Journal of Infectious Diseases
Avian influenza virus
Genetic analysis
H7N9
Influenza surveillance
Mutations
title Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
title_full Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
title_fullStr Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
title_full_unstemmed Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
title_short Isolation and characteristic analysis of a novel strain H7N9 of avian influenza virus A from a patient with influenza-like symptoms in China
title_sort isolation and characteristic analysis of a novel strain h7n9 of avian influenza virus a from a patient with influenza like symptoms in china
topic Avian influenza virus
Genetic analysis
H7N9
Influenza surveillance
Mutations
url http://www.sciencedirect.com/science/article/pii/S1201971215000181
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