Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial
Background: Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects Objective/hypothesis: To test the use of ECT to disrupt the reconsolidation of trau...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Brain Stimulation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X21000668 |
| _version_ | 1818444121964019712 |
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| author | Victor M. Tang Kathleen Trought Kristina M. Gicas Mari Kozak Sheena A. Josselyn Zafiris J. Daskalakis Daniel M. Blumberger Daphne Voineskos Yuliya Knyahnytska Suvercha Pasricha Yuan Chung Young Zhou Moshe Isserles Albert H.C. Wong |
| author_facet | Victor M. Tang Kathleen Trought Kristina M. Gicas Mari Kozak Sheena A. Josselyn Zafiris J. Daskalakis Daniel M. Blumberger Daphne Voineskos Yuliya Knyahnytska Suvercha Pasricha Yuan Chung Young Zhou Moshe Isserles Albert H.C. Wong |
| author_sort | Victor M. Tang |
| collection | DOAJ |
| description | Background: Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects Objective/hypothesis: To test the use of ECT to disrupt the reconsolidation of traumatic memories as a potential treatment for PTSD Methods: Participants were adults from the civilian population and were referred for ECT treatment for severe depression with comorbid PTSD symptoms. Twenty-eight participants were randomly assigned to reactivation of a traumatic or non-traumatic memory using audio script driven imagery prior to each ECT treatment. Primary outcomes were change in scores on the Modified PTSD Symptom Scale - Self Report (MPSS-SR) and the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). Secondary outcomes included a comparison of the change in heart rate while listening to the script Results: Twenty-five female patients who completed a post-ECT assessment were included in the analysis. No significant group differences were found in the MPSS-SR or CAPS-5 scores from pre-ECT to post-ECT or 3-month follow-ups. However, both groups improved at post-ECT and 3-month follow up. Partial eta squared estimates of effect size showed large effect sizes for all outcomes (η2 > 0.13). Changes in heart rate were not significantly different between groups or over time Conclusions: ECT paired with pre-treatment traumatic memory reactivation was not more effective for treating PTSD symptoms than ECT with non-traumatic memory reactivation. While our primary hypothesis was not supported, our data provides further support for the efficacy of ECT for improving symptoms of PTSD with comorbid depression.ClinicalTrials.gov.https://clinicaltrials.gov/ct2/show/NCT04027452. Identifier: NCT04027452. |
| first_indexed | 2024-12-14T19:10:54Z |
| format | Article |
| id | doaj.art-383e53c52400473194ed362c3dd12d9c |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-12-14T19:10:54Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-383e53c52400473194ed362c3dd12d9c2022-12-21T22:50:43ZengElsevierBrain Stimulation1935-861X2021-05-01143635642Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trialVictor M. Tang0Kathleen Trought1Kristina M. Gicas2Mari Kozak3Sheena A. Josselyn4Zafiris J. Daskalakis5Daniel M. Blumberger6Daphne Voineskos7Yuliya Knyahnytska8Suvercha Pasricha9Yuan Chung10Young Zhou11Moshe Isserles12Albert H.C. Wong13Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychiatry, University of Toronto, Ontario, CanadaProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Ontario, Canada; Department of Psychology, University of Toronto, Toronto, Ontario, CanadaDepartment of Psychiatry, UC San Diego Health, La Jolla, California, USACampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, CanadaDepartment of Psychiatry, University of Toronto, Ontario, CanadaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Ontario, CanadaThe Jerusalem Center for Mental Health, Jerusalem, IsraelCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Ontario, Canada; Corresponding author. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.Background: Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects Objective/hypothesis: To test the use of ECT to disrupt the reconsolidation of traumatic memories as a potential treatment for PTSD Methods: Participants were adults from the civilian population and were referred for ECT treatment for severe depression with comorbid PTSD symptoms. Twenty-eight participants were randomly assigned to reactivation of a traumatic or non-traumatic memory using audio script driven imagery prior to each ECT treatment. Primary outcomes were change in scores on the Modified PTSD Symptom Scale - Self Report (MPSS-SR) and the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). Secondary outcomes included a comparison of the change in heart rate while listening to the script Results: Twenty-five female patients who completed a post-ECT assessment were included in the analysis. No significant group differences were found in the MPSS-SR or CAPS-5 scores from pre-ECT to post-ECT or 3-month follow-ups. However, both groups improved at post-ECT and 3-month follow up. Partial eta squared estimates of effect size showed large effect sizes for all outcomes (η2 > 0.13). Changes in heart rate were not significantly different between groups or over time Conclusions: ECT paired with pre-treatment traumatic memory reactivation was not more effective for treating PTSD symptoms than ECT with non-traumatic memory reactivation. While our primary hypothesis was not supported, our data provides further support for the efficacy of ECT for improving symptoms of PTSD with comorbid depression.ClinicalTrials.gov.https://clinicaltrials.gov/ct2/show/NCT04027452. Identifier: NCT04027452.http://www.sciencedirect.com/science/article/pii/S1935861X21000668Electroconvulsive therapyPost-traumatic stress disorderReconsolidationMemoryImageryStress disorders |
| spellingShingle | Victor M. Tang Kathleen Trought Kristina M. Gicas Mari Kozak Sheena A. Josselyn Zafiris J. Daskalakis Daniel M. Blumberger Daphne Voineskos Yuliya Knyahnytska Suvercha Pasricha Yuan Chung Young Zhou Moshe Isserles Albert H.C. Wong Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial Brain Stimulation Electroconvulsive therapy Post-traumatic stress disorder Reconsolidation Memory Imagery Stress disorders |
| title | Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial |
| title_full | Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial |
| title_fullStr | Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial |
| title_full_unstemmed | Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial |
| title_short | Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial |
| title_sort | electroconvulsive therapy with a memory reactivation intervention for post traumatic stress disorder a randomized controlled trial |
| topic | Electroconvulsive therapy Post-traumatic stress disorder Reconsolidation Memory Imagery Stress disorders |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X21000668 |
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