Transcatheter Mitral Valve Replacement and Thrombosis: A Review
Mitral regurgitation is the most prevalent form of moderate or severe valve disease in developed countries. Surgery represents the standard of care for symptomatic patients with severe mitral regurgitation, but up to 50% of patients are denied surgery because of high surgical risk. In this context,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.621258/full |
| _version_ | 1819098625865678848 |
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| author | Guido Ascione Paolo Denti |
| author_facet | Guido Ascione Paolo Denti |
| author_sort | Guido Ascione |
| collection | DOAJ |
| description | Mitral regurgitation is the most prevalent form of moderate or severe valve disease in developed countries. Surgery represents the standard of care for symptomatic patients with severe mitral regurgitation, but up to 50% of patients are denied surgery because of high surgical risk. In this context, different transcatheter options have been developed to address this unmet need. Transcatheter mitral valve replacement (TMVR) is an emergent field representing an alternative option in high complex contexts when transcatheter mitral valve repair is not feasible or suboptimal due to anatomical issues. However, TMVR is burdened by some device-specific issues (device malposition, migration or embolization, left ventricular outflow tract obstruction, hemolysis, thrombosis, stroke). Here we discuss the thrombotic risk of TMVR and current evidence about anticoagulation therapy after TMVR. |
| first_indexed | 2024-12-22T00:33:58Z |
| format | Article |
| id | doaj.art-383eeebf8d8941a4af4efa95a4ab9795 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T00:33:58Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-383eeebf8d8941a4af4efa95a4ab97952022-12-21T18:44:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-06-01810.3389/fcvm.2021.621258621258Transcatheter Mitral Valve Replacement and Thrombosis: A ReviewGuido AscionePaolo DentiMitral regurgitation is the most prevalent form of moderate or severe valve disease in developed countries. Surgery represents the standard of care for symptomatic patients with severe mitral regurgitation, but up to 50% of patients are denied surgery because of high surgical risk. In this context, different transcatheter options have been developed to address this unmet need. Transcatheter mitral valve replacement (TMVR) is an emergent field representing an alternative option in high complex contexts when transcatheter mitral valve repair is not feasible or suboptimal due to anatomical issues. However, TMVR is burdened by some device-specific issues (device malposition, migration or embolization, left ventricular outflow tract obstruction, hemolysis, thrombosis, stroke). Here we discuss the thrombotic risk of TMVR and current evidence about anticoagulation therapy after TMVR.https://www.frontiersin.org/articles/10.3389/fcvm.2021.621258/fulltranscatheter mitral valve replacementthrombosisvitamin K antagonistsnon-vitamin K antagonist oral anticoagulantsmitral valve regurgitation |
| spellingShingle | Guido Ascione Paolo Denti Transcatheter Mitral Valve Replacement and Thrombosis: A Review Frontiers in Cardiovascular Medicine transcatheter mitral valve replacement thrombosis vitamin K antagonists non-vitamin K antagonist oral anticoagulants mitral valve regurgitation |
| title | Transcatheter Mitral Valve Replacement and Thrombosis: A Review |
| title_full | Transcatheter Mitral Valve Replacement and Thrombosis: A Review |
| title_fullStr | Transcatheter Mitral Valve Replacement and Thrombosis: A Review |
| title_full_unstemmed | Transcatheter Mitral Valve Replacement and Thrombosis: A Review |
| title_short | Transcatheter Mitral Valve Replacement and Thrombosis: A Review |
| title_sort | transcatheter mitral valve replacement and thrombosis a review |
| topic | transcatheter mitral valve replacement thrombosis vitamin K antagonists non-vitamin K antagonist oral anticoagulants mitral valve regurgitation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.621258/full |
| work_keys_str_mv | AT guidoascione transcathetermitralvalvereplacementandthrombosisareview AT paolodenti transcathetermitralvalvereplacementandthrombosisareview |