Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites
Vector-borne pathogens are known to elicit immune response upon mosquito biting the host which is critically linked to the establishment of infection and pathogenesis of disease, yet the impact of the mosquito bite itself is not immunologically well-appreciated. Here the authors characterize the imm...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34534-9 |
| _version_ | 1811217066240245760 |
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| author | David Guerrero Hoa Thi My Vo Chanthap Lon Jennifer A. Bohl Sreynik Nhik Sophana Chea Somnang Man Sokunthea Sreng Andrea R. Pacheco Sokna Ly Rathanak Sath Sokchea Lay Dorothée Missé Rekol Huy Rithea Leang Hok Kry Jesus G. Valenzuela Fabiano Oliveira Tineke Cantaert Jessica E. Manning |
| author_facet | David Guerrero Hoa Thi My Vo Chanthap Lon Jennifer A. Bohl Sreynik Nhik Sophana Chea Somnang Man Sokunthea Sreng Andrea R. Pacheco Sokna Ly Rathanak Sath Sokchea Lay Dorothée Missé Rekol Huy Rithea Leang Hok Kry Jesus G. Valenzuela Fabiano Oliveira Tineke Cantaert Jessica E. Manning |
| author_sort | David Guerrero |
| collection | DOAJ |
| description | Vector-borne pathogens are known to elicit immune response upon mosquito biting the host which is critically linked to the establishment of infection and pathogenesis of disease, yet the impact of the mosquito bite itself is not immunologically well-appreciated. Here the authors characterize the immune response to the mosquito vector Aedes aegypti in a controlled human in vivo challenge model and show the induction of a range of immune pathways and cell types. |
| first_indexed | 2024-04-12T06:48:55Z |
| format | Article |
| id | doaj.art-383fba8e8ce84dacad9791a58dda3ad1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T06:48:55Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-383fba8e8ce84dacad9791a58dda3ad12022-12-22T03:43:26ZengNature PortfolioNature Communications2041-17232022-11-0113111310.1038/s41467-022-34534-9Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bitesDavid Guerrero0Hoa Thi My Vo1Chanthap Lon2Jennifer A. Bohl3Sreynik Nhik4Sophana Chea5Somnang Man6Sokunthea Sreng7Andrea R. Pacheco8Sokna Ly9Rathanak Sath10Sokchea Lay11Dorothée Missé12Rekol Huy13Rithea Leang14Hok Kry15Jesus G. Valenzuela16Fabiano Oliveira17Tineke Cantaert18Jessica E. Manning19Institut Pasteur du Cambodge, Pasteur NetworkInstitut Pasteur du Cambodge, Pasteur NetworkInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInstitut Pasteur du Cambodge, Pasteur NetworkMIVEGEC, Univ. Montpellier, IRD, CNRSNational Center of Parasitology, Entomology, and Malaria ControlNational Center of Parasitology, Entomology, and Malaria ControlKampong Speu Provincial District, Ministry of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInstitut Pasteur du Cambodge, Pasteur NetworkInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVector-borne pathogens are known to elicit immune response upon mosquito biting the host which is critically linked to the establishment of infection and pathogenesis of disease, yet the impact of the mosquito bite itself is not immunologically well-appreciated. Here the authors characterize the immune response to the mosquito vector Aedes aegypti in a controlled human in vivo challenge model and show the induction of a range of immune pathways and cell types.https://doi.org/10.1038/s41467-022-34534-9 |
| spellingShingle | David Guerrero Hoa Thi My Vo Chanthap Lon Jennifer A. Bohl Sreynik Nhik Sophana Chea Somnang Man Sokunthea Sreng Andrea R. Pacheco Sokna Ly Rathanak Sath Sokchea Lay Dorothée Missé Rekol Huy Rithea Leang Hok Kry Jesus G. Valenzuela Fabiano Oliveira Tineke Cantaert Jessica E. Manning Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites Nature Communications |
| title | Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| title_full | Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| title_fullStr | Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| title_full_unstemmed | Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| title_short | Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| title_sort | evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites |
| url | https://doi.org/10.1038/s41467-022-34534-9 |
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