Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations

Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations

Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it consumes large amounts of samples when used for formulation development. Herein, we show a novel approach to screen the polymers by overcoming the disadvantag...

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Bibliographic Details
Main Authors:	Gauri Shadambikar, Thomas Kipping, Nicole Di-Gallo, Alessandro-Giuseppe Elia, Anja-Nadine Knüttel, Daniel Treffer, Michael. A Repka
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Pharmaceutics
Subjects:	polyvinyl alcohol screening tool hot-melt extrusion amorphous solid dispersion formulation development
Online Access:	https://www.mdpi.com/1999-4923/12/11/1019

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