Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature
Extrarenal rhabdoid tumor (ERRT) is a rare, aggressive tumor with extremely poor prognosis. We report a case of ERRT with intraspinal extension in a 1.5-year-old child diagnosed by fine needle aspiration cytology (FNAC) and immunohistochemistry. The child presented with a right lumbar region lump of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=819;epage=821;aulast=Jain |
| _version_ | 1817971372125585408 |
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| author | Manjula Jain Aparna Harbhajanka S Roy Choudhary |
| author_facet | Manjula Jain Aparna Harbhajanka S Roy Choudhary |
| author_sort | Manjula Jain |
| collection | DOAJ |
| description | Extrarenal rhabdoid tumor (ERRT) is a rare, aggressive tumor with extremely poor prognosis. We report a case of ERRT with intraspinal extension in a 1.5-year-old child diagnosed by fine needle aspiration cytology (FNAC) and immunohistochemistry. The child presented with a right lumbar region lump of two months duration. Ultrasound guided FNAC was performed and cell block was prepared. Smears were highly cellular and showed a dispersed population of large round cells having abundant pale eosinophillic cytoplasm, centrally to eccentrically placed nucleus with large prominent nucleoli. Immunohistochemistry was carried out on cell block which was positive for epithelial membrane antigen EMA and Vimentin. It was negative for leucocyte common antigen [LCA], wilms tumor 1, WT1, desmin and neuron specific enolaseNSE, thus ruling out other tumors like lymphoma, Wilms tumor, rhabdomyosarcoma, and neuroblastoma. A final diagnosis of ERRT was given. ERRT is an extremely rare tumor of retroperitoneal area; it should be included in the differential diagnosis of malignant round cell tumor in children. Cell block in this case is mandatory for putting up the panel of immunohistochemistry which can clinch the diagnosis of rhabdoid tumor and treatment can be started as early as possible. |
| first_indexed | 2024-04-13T20:45:58Z |
| format | Article |
| id | doaj.art-3840968a2ad9437089353c6ee39c52f8 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-13T20:45:58Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-3840968a2ad9437089353c6ee39c52f82022-12-22T02:30:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-0154481982110.4103/0377-4929.91534Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literatureManjula JainAparna HarbhajankaS Roy ChoudharyExtrarenal rhabdoid tumor (ERRT) is a rare, aggressive tumor with extremely poor prognosis. We report a case of ERRT with intraspinal extension in a 1.5-year-old child diagnosed by fine needle aspiration cytology (FNAC) and immunohistochemistry. The child presented with a right lumbar region lump of two months duration. Ultrasound guided FNAC was performed and cell block was prepared. Smears were highly cellular and showed a dispersed population of large round cells having abundant pale eosinophillic cytoplasm, centrally to eccentrically placed nucleus with large prominent nucleoli. Immunohistochemistry was carried out on cell block which was positive for epithelial membrane antigen EMA and Vimentin. It was negative for leucocyte common antigen [LCA], wilms tumor 1, WT1, desmin and neuron specific enolaseNSE, thus ruling out other tumors like lymphoma, Wilms tumor, rhabdomyosarcoma, and neuroblastoma. A final diagnosis of ERRT was given. ERRT is an extremely rare tumor of retroperitoneal area; it should be included in the differential diagnosis of malignant round cell tumor in children. Cell block in this case is mandatory for putting up the panel of immunohistochemistry which can clinch the diagnosis of rhabdoid tumor and treatment can be started as early as possible.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=819;epage=821;aulast=JainExtrarenalimmunohistochemistryneedle biopsyrhabdoidtumor |
| spellingShingle | Manjula Jain Aparna Harbhajanka S Roy Choudhary Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature Indian Journal of Pathology and Microbiology Extrarenal immunohistochemistry needle biopsy rhabdoid tumor |
| title | Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature |
| title_full | Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature |
| title_fullStr | Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature |
| title_full_unstemmed | Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature |
| title_short | Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature |
| title_sort | cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor a case report with review of literature |
| topic | Extrarenal immunohistochemistry needle biopsy rhabdoid tumor |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=819;epage=821;aulast=Jain |
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