Comparison of the DNA-binding interactions of 5-hydroxymethylfurfural and its synthesized derivative, 5, 5’[oxy-bis(methylene)]bis-2-furfural: experimental, DFT and docking studies

Comparison of the DNA-binding interactions of 5-hydroxymethylfurfural and its synthesized derivative, 5, 5’[oxy-bis(methylene)]bis-2-furfural: experimental, DFT and docking studies

In this study, the in vitro DNA-binding interactions of the food/drug additive, 5-hydroxymethylfurfural (HMF) and its major degradant, 5, 5'[oxy-bis(methylene)]bis-2-furfural (OBMF) were investigated. OBMF was synthesized and characterized using IR, NMR and mass spectrometry. Photometric titrat...

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Bibliographic Details
Main Authors: Olusegun Emmanuel Thomas, Rashidat Temitope Oduwole, Akintayo Akin-Taylor
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Taibah University for Science
Subjects:
Hydroxymethylfurfural
DNA viscosity study
density functional theory
molecular modelling
structure-activity relationships
Online Access:https://www.tandfonline.com/doi/10.1080/16583655.2023.2183705

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