DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review
Background:. Acellular dermal matrices (ADMs) are commonly used in tissue expander and direct-to-implant reconstruction following mastectomy. Few studies have reported outcomes of DermACELL use or compared DermACELL with AlloDerm ADM. This study sought to compare outcomes of DermACELL and AlloDerm i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-06-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004396 |
| _version_ | 1811332754261934080 |
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| author | Austin R. Swisher, BS Mark J. Landau, MD, PhD Nikita Kadakia, MD Stephanie W. Holzmer, MD Hahns Y. Kim, MD |
| author_facet | Austin R. Swisher, BS Mark J. Landau, MD, PhD Nikita Kadakia, MD Stephanie W. Holzmer, MD Hahns Y. Kim, MD |
| author_sort | Austin R. Swisher, BS |
| collection | DOAJ |
| description | Background:. Acellular dermal matrices (ADMs) are commonly used in tissue expander and direct-to-implant reconstruction following mastectomy. Few studies have reported outcomes of DermACELL use or compared DermACELL with AlloDerm ADM. This study sought to compare outcomes of DermACELL and AlloDerm in oncologic breast reconstruction and to review the literature reporting outcomes of patients undergoing reconstruction using DermACELL.
Methods:. We conducted a retrospective cohort study to compare outcomes between DermACELL and AlloDerm ADM, and a systematic review of the literature with a meta-analysis to evaluate clinical outcomes with DermACELL.
Results:. Seventy-four patients (128 breasts) undergoing immediate reconstruction were evaluated retrospectively. Chi-square analysis revealed no significant difference in postoperative outcomes between the two groups. Our systematic review of the literature yielded 12 total studies reporting DermACELL use for breast reconstruction encompassing 518 patients and 608 total breasts. A pooled analysis of the published data did not reveal a significant change in the rate of explantation when either chemotherapy or radiation was used. Meta-analysis did not show a significant difference in the rate of any of the complications evaluated.
Conclusion:. DermACELL is safe to use with a relatively consistent complication profile as compared with AlloDerm. |
| first_indexed | 2024-04-13T16:41:44Z |
| format | Article |
| id | doaj.art-38420ab8a4dd4b1fa087d766adedadcb |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-04-13T16:41:44Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-38420ab8a4dd4b1fa087d766adedadcb2022-12-22T02:39:13ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742022-06-01106e439610.1097/GOX.0000000000004396202206000-00043DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic ReviewAustin R. Swisher, BS0Mark J. Landau, MD, PhD1Nikita Kadakia, MD2Stephanie W. Holzmer, MD3Hahns Y. Kim, MD4From the * Department of Surgery, University of California, Riverside School of Medicine, Riverside, Calif.† Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.† Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.† Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.† Department of Plastic Surgery, Loma Linda University, Loma Linda, Calif.Background:. Acellular dermal matrices (ADMs) are commonly used in tissue expander and direct-to-implant reconstruction following mastectomy. Few studies have reported outcomes of DermACELL use or compared DermACELL with AlloDerm ADM. This study sought to compare outcomes of DermACELL and AlloDerm in oncologic breast reconstruction and to review the literature reporting outcomes of patients undergoing reconstruction using DermACELL. Methods:. We conducted a retrospective cohort study to compare outcomes between DermACELL and AlloDerm ADM, and a systematic review of the literature with a meta-analysis to evaluate clinical outcomes with DermACELL. Results:. Seventy-four patients (128 breasts) undergoing immediate reconstruction were evaluated retrospectively. Chi-square analysis revealed no significant difference in postoperative outcomes between the two groups. Our systematic review of the literature yielded 12 total studies reporting DermACELL use for breast reconstruction encompassing 518 patients and 608 total breasts. A pooled analysis of the published data did not reveal a significant change in the rate of explantation when either chemotherapy or radiation was used. Meta-analysis did not show a significant difference in the rate of any of the complications evaluated. Conclusion:. DermACELL is safe to use with a relatively consistent complication profile as compared with AlloDerm.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004396 |
| spellingShingle | Austin R. Swisher, BS Mark J. Landau, MD, PhD Nikita Kadakia, MD Stephanie W. Holzmer, MD Hahns Y. Kim, MD DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review Plastic and Reconstructive Surgery, Global Open |
| title | DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review |
| title_full | DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review |
| title_fullStr | DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review |
| title_full_unstemmed | DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review |
| title_short | DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review |
| title_sort | dermacell acellular dermal matrix in oncologic breast reconstruction a cohort study and systematic review |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004396 |
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